Journal
JOURNAL OF BIOMATERIALS APPLICATIONS
Volume 37, Issue 5, Pages 942-958Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/08853282221117209
Keywords
3D printing; porous titanium alloy; dihydroxyphenylalanine; RGD; BMP-2; osseointegration
Funding
- Changzhou Science and Technology Project Fund [CQ20214029]
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By incorporating designed peptide conjugates onto 3D printed porous titanium alloy scaffolds, the osseointegration and mechanical stability can be significantly enhanced, addressing the weak bond between titanium alloy implants and bone tissue.
The 3D printed porous titanium alloy scaffolds are beneficial to enhance angiogenesis, osteoblast adhesion, and promote osseointegration. However, titanium alloys are biologically inert, which makes the bond between the implant and bone tissue weak and prone to loosening. Inspired by the natural biological marine mussels, we designed four-claw-shaped mussel-derived bioactive peptides for the decoration of porous titanium alloy scaffolds: adhesion peptide-DOPA, anchoring peptide-RGD and osteogenic-inducing peptide-BMP-2. And the bifunctionalization of 3D-printed porous titanium alloy scaffolds was evaluated in vivo in a rabbit model of bone defect with excellent promotion of osseointegration and mechanical stability. Our results show that the in vivo osseointegration ability of the modified 3D printed porous titanium alloy test piece is significantly improved, and the bifunctional polypeptide coating group E has the strongest osseointegration ability. In conclusion, our experimental design partially solves the problems of stress shielding effect and biological inertness, and provides a convenient and feasible method for the clinical application of titanium alloy implants in biomedical implant materials.
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