Journal
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
Volume 36, Issue 9, Pages -Publisher
WILEY
DOI: 10.1002/jbt.23120
Keywords
bisphenol A; estrus cycle; granulosa cells; oxidative stress; resveratrol
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Funding
- China Agriculture Research System of MOF
- MARA [CARS-35]
- Key Research and Development Program of Shaanxi Province [2022ZDLNY01-04]
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The study found that BPA disrupted the normal estrus cycle in mice and induced oxidative stress, autophagy, and apoptosis in ovaries and granulosa cells. Supplementation with resveratrol protected ovarian granulosa cells and alleviated the toxic effects of BPA.
Bisphenol A (BPA), as a widely used plasticizer, is easily absorbed by animals and humans. It has certain toxic effects on various tissues, including liver, heart, kidney, testis, and ovary. The toxic effects of BPA on animal reproduction have aroused widespread concern, but its regulatory mechanism and antidote in female animals estrus cycle remain unclear. In this study, the results displayed that BPA destroyed the normal estrus cycle of mice through decreasing the levels of progesterone and estradiol. Furthermore, BPA significantly increased the levels of oxidative stress, autophagy, and apoptosis in ovaries and granulosa cells. Interestingly, we found that the natural antioxidant resveratrol rescued estrus disorder and impaired estradiol secretion, reduced the abnormal reactive oxygen species accumulation, autophagy, and apoptosis in BPA exposed ovarian tissues. Moreover, transmission electron microscopy showed that resveratrol reduced BPA-induced autophagic vesicles formation and flow cytometry showed that resveratrol inhibited the increase of apoptotic cells induced by BPA on granulosa cells. Therefore, the supplement of resveratrol could restore BPA-induced estrus disorder by protecting ovarian granulosa cells. Overall, resveratrol is a potential drug to alleviate BPA-induced estrous cycle disorders and ovarian damage.
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