Journal
JOURNAL OF ATTENTION DISORDERS
Volume 26, Issue 14, Pages 1895-1906Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/10870547221110918
Keywords
ADHD; cortical thickness; superior frontal gyrus; executive functions
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Funding
- Alberta Children's Hospital Foundation
- Werklund School of Education (University of Calgary)
- Scientific Director of the Strategic Clinical Network for Addictions and Mental Health from Alberta Health Services
- Branch Out Neurological Foundation
- Canadian Institute for Health Research (CIHR)
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We found that the right Superior Frontal Gyrus was thinner in children with ADHD, and this thickness was associated with inattentive and hyperactive symptoms as well as executive function.
Objective: We investigated the right Superior Frontal Gyrus (right-SFG) and Anterior Cingulate Cortex (ACC) in children with ADHD and their clinical relevance with Executive Function (EF) and ADHD symptom severity. Methods: About 26 children with ADHD and 24 typically developing children (TDC; 7-16 years) underwent Magnetic Resonance Imaging (MRI) and completed an EF assessment battery. Results: Significantly thinner right-SFG in the ADHD group was found compared to the TDC group (t (48) = 2.81, p = .007, Cohen's d = 0.84). Linear regression models showed that 12.5% of inattention, 13.6% of hyperactivity, and 9.0% of EF variance was accounted for by the right-SFG thickness. Conclusions: Differences in the right-SFG thickness were found in our ADHD group and were associated with parent ratings of inattentive and hyperactive symptoms as well with EF ratings. These results replicate previous findings of thinner right-SFG and are consistent with the delayed cortical maturation theory of ADHD.
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