Penicipurate A, a new polyketide derivative from the endophytic fungus Penicillium purpurogenum

A new polyketide derivative containing a 3-hydroxydecanoic acid ester moiety, penicipurate A (1), was purified from the solid cultures of the fungus Penicillium purpurogenum, a fungal strain endophytic in the leaves of Edgeworthia chrysantha. The structure of 1 was established by spectroscopic methods, including UV, IR, HRESIMS, 1D, and 2D NMR and C-13 NMR chemical shifts calculations coupled with DP4+ analysis, as well as the chemical degradation method. Compound 1 showed moderate inhibitory activity against pancreatic lipase (PL) with an IC50 value of 9.61 +/- 1.42 mu M.

Automated summary

A new polyketide derivative penicipurate A (1) containing a 3-hydroxydecanoic acid ester moiety was isolated from the solid cultures of the endophytic fungal strain Penicillium purpurogenum in the leaves of Edgeworthia chrysantha. The structure of 1 was determined using various spectroscopic methods and chemical degradation. Compound 1 exhibited moderate inhibitory activity against pancreatic lipase.