Journal
JOURNAL OF APPLIED TOXICOLOGY
Volume 43, Issue 1, Pages 122-145Publisher
WILEY
DOI: 10.1002/jat.4360
Keywords
Caenorhabditis elegans; environmental pollutants; in vivo model; multigenerational toxicity; transgenerational toxicity
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This review summarizes the transgenerational and multigenerational toxicity caused by various environmental pollutants in Caenorhabditis elegans and discusses the underlying mechanisms.
A large number of pollutants existing in the environment can last for a long time, and their potential toxic effects can transfer from parents to their offspring. Thus, it is necessary to investigate the toxicity of environmental pollutants across multigenerations and the underlying mechanisms in organisms. Due to its short life cycle and sensitivity to environmental exposures, Caenorhabditis elegans is an important animal model for toxicity assessment of environmental pollutants across multigenerations. In this review, we introduced the transgenerational and multigenerational toxicity caused by various environmental pollutants in C. elegans. Moreover, we discussed the underlying mechanisms for the observed transgenerational and multigenerational toxicity of environmental contaminants in C. elegans.
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