Journal
JOURNAL OF ALZHEIMERS DISEASE
Volume 88, Issue 4, Pages 1371-1376Publisher
IOS PRESS
DOI: 10.3233/JAD-220343
Keywords
Alzheimer's disease; cognition; liver enzymes; neuropsychological assessment
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Funding
- National Research Foundation of Korea - Korean government (Ministry of Science and ICT) [2020R1C1C1013718]
- National Research Foundation of Korea [2020R1C1C1013718] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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This study suggests that serum liver enzymes are associated with Alzheimer's disease diagnosis and cognitive performance. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels are positively associated with cognitive performance and decreased in AD patients. On the other hand, alkaline phosphatase level and AST to ALT ratio are negatively associated with cognitive performance and increased in AD patients.
To investigate an association of serum liver enzymes with Alzheimer's disease (AD) diagnosis and cognitive performance, we performed logistic and linear regression analyses in 781 patients with AD and 405 cognitively normal subjects. We found that alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels had significant positive associations with cognitive performance and were significantly decreased in AD patients. The alkaline phosphatase level and AST to ALT ratio were significantly negatively associated with cognitive performance and were significantly increased in AD patients. This suggests that these liver enzymes might be implicated in the pathogenesis of AD.
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