4.7 Article

Chlorogenic Acid Prevents Hyperuricemia Nephropathy via Regulating TMAO-Related Gut Microbes and Inhibiting the PI3K/ AKT/mTOR Pathway

Related references

Note: Only part of the references are listed.
Article Plant Sciences

Diaphragma juglandis extracts modifies the gut microbiota during prevention of type 2 diabetes in rats

Feng Zhang et al.

Summary: The study found that diaphragma juglandis extract could improve metabolic abnormalities in type 2 diabetic rats, including insulin resistance, abnormal lipid metabolism, liver damage, oxidative stress, and reduce inflammation. It also prevented the pathological damage of pancreas and liver, and intercepted the disorders of gut microbes.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

Article Pharmacology & Pharmacy

Metabolomics analysis of human plasma reveals decreased production of trimethylamine N-oxide retards the progression of chronic kidney disease

Da-Yong Hu et al.

Summary: The study found that reducing the production of trimethylamine N-oxide (TMAO) may be a new strategy to attenuate the progression of renal injury in chronic kidney disease (CKD). The effects of TMAO were validated in patients with uraemia and mouse models, showing its potential as a marker and therapeutic target for CKD.

BRITISH JOURNAL OF PHARMACOLOGY (2022)

Article Environmental Sciences

Multi-omics reveals that Bifidobacterium breve M-16V may alleviate the immune dysregulation caused by nanopolystyrene

Na Li et al.

Summary: This study established a comprehensive phenotyping and multi-omics analysis method to evaluate the toxicity of nanopolystyrene (PS) on mice. The results showed that PS exposure caused microbial alteration, metabolic disorders, and immune disturbances. Additionally, the probiotic Bifidobacterium breve M-16V was found to have anti-inflammatory and immunomodulatory effects through host-microbiome interactions.

ENVIRONMENT INTERNATIONAL (2022)

Article Pharmacology & Pharmacy

Pharmacological targeting macrophage phenotype via gut-kidney axis ameliorates renal fibrosis in mice

Yanan Xie et al.

Summary: This study demonstrates that modulating macrophage phenotype via the gut-kidney axis can alleviate renal fibrosis in chronic kidney disease. Antibiotics treatment reduces renal fibrosis by limiting the synthesis of Trimethylamine N-Oxide (TMAO) in intestinal flora metabolite. Furthermore, the NLRP3 inflammasome plays a critical role in macrophage polarization. Metabolites can regulate macrophage phenotype, which impacts the severity of renal fibrosis.

PHARMACOLOGICAL RESEARCH (2022)

Article Biotechnology & Applied Microbiology

Integrated metagenomics identifies a crucial role for trimethylamine-producing Lachnoclostridium in promoting atherosclerosis

Yuan-Yuan Cai et al.

Summary: This study identified bacterial genera containing trimethylamine (TMA) lyase and their ability to convert choline into TMA, promoting the development of atherosclerosis. Lachnoclostridium and Clostridium were found to be the most abundant genera containing the cutC gene, which is involved in the TMA production pathway. In vitro experiments showed that L. saccharolyticum efficiently transformed choline into TMA, and in vivo studies demonstrated that treatment with L. saccharolyticum and choline increased TMAO levels and aortic plaque accumulation in ApoE(-/-) mice.

NPJ BIOFILMS AND MICROBIOMES (2022)

Article Cardiac & Cardiovascular Systems

Yellow Wine Polyphenolic Compound Protects Against Doxorubicin-Induced Cardiotoxicity by Modulating the Composition and Metabolic Function of the Gut Microbiota

Hui Lin et al.

Summary: The study showed that yellow wine polyphenolic compound (YWPC) alleviated doxorubicin-induced cardiotoxicity through modulating gut microbiota and associated metabolites. Antibiotic treatment exacerbated cardiotoxicity and partly abolished the cardioprotective effects of YWPC, highlighting the essential role of gut microbiota in the cardioprotective role of YWPC.

CIRCULATION-HEART FAILURE (2021)

Article Agriculture, Multidisciplinary

Protection Mechanisms Underlying Oral Administration of Chlorogenic Acid against Cadmium-Induced Hepatorenal Injury Related to Regulating Intestinal Flora Balance

Yixin Ding et al.

Summary: Chlorogenic acid (CGA) can prevent cadmium toxicity by regulating intestinal flora balance protection mechanisms. This study found that CGA can effectively alleviate liver and kidney damage caused by cadmium in mice.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

Article Food Science & Technology

Chlorogenic Acid Alleviates Hyperglycemia-Induced Cardiac Fibrosis through Activation of the NO/cGMP/PKG Pathway in Cardiac Fibroblasts

Linhui Qin et al.

Summary: Chlorogenic acid (CGA) can inhibit hyperglycemia-induced cardiac fibrosis by activating the cGMP/PKG pathway, improve cardiac function, in addition to lowering blood glucose levels. It has an independent ability to inhibit cardiac fibrosis, which can be beneficial for diabetic patients consuming foods rich in CGA in the long term.

MOLECULAR NUTRITION & FOOD RESEARCH (2021)

Article Biochemistry & Molecular Biology

The Fibrotic Effects of TMAO on Human Renal Fibroblasts Is Mediated by NLRP3, Caspase-1 and the PERK/Akt/mTOR Pathway

Stefania Kapetanaki et al.

Summary: TMAO activates and proliferates renal fibroblasts via the PERK/Akt/mTOR pathway, NLRP3, and caspase-1 signaling, leading to fibrosis, while not inducing the release of fibronectin or TGF-beta 1 from renal fibroblasts.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Multidisciplinary Sciences

Inhibition of microbiota-dependent TMAO production attenuates chronic kidney disease in mice

Wenchao Zhang et al.

Summary: Inhibition of trimethylamine N-oxide (TMAO) production was found to attenuate the development of chronic kidney disease (CKD) and cardiac hypertrophy in mice, suggesting that reducing TMAO levels may be a novel strategy in treating CKD and its cardiovascular disease complications.

SCIENTIFIC REPORTS (2021)

Article Cell Biology

The probiotic L. casei Zhang slows the progression of acute and chronic kidney disease

Han Zhu et al.

Summary: The study demonstrates that oral administration of the probiotic Lactobacillus casei Zhang can correct gut microbial dysbiosis, alleviate kidney injury, and delay the progression of chronic kidney disease. By increasing levels of SCFAs and nicotinamide, L. casei Zhang shows potential as a therapy to reduce renal inflammation and slow the decline of kidney function.

CELL METABOLISM (2021)

Article Agriculture, Multidisciplinary

Lactobacillus rhamnosus LRa05 Ameliorate Hyperglycemia through a Regulating Glucagon-Mediated Signaling Pathway and Gut Microbiota in Type 2 Diabetic Mice

Tao Wu et al.

Summary: The study shows that LRaOS can effectively reduce fasting blood glucose levels in T2DM mice, alleviate insulin resistance and hepatic oxidative stress, and reshape the gut microbiota composition.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

Article Agriculture, Multidisciplinary

Fisetin Improves Hyperuricemia-Induced Chronic Kidney Disease via Regulating Gut Microbiota-Mediated Tryptophan Metabolism and Aryl Hydrocarbon Receptor Activation

Qian Ren et al.

Summary: Fisetin protects against hyperuricemia-induced chronic kidney disease by modulating gut microbiota-mediated tryptophan metabolism and AHR activation.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

Article Gastroenterology & Hepatology

Limosilactobacillus fermentum JL-3 isolated from Jiangshui ameliorates hyperuricemia by degrading uric acid

Ying Wu et al.

Summary: The study found that Limosilactobacillus fermentum JL-3 strain, isolated from a fermented Chinese food, showed high degradation capacity and selectivity toward uric acid. After oral administration to mice for 15 days, JL-3 colonization was continuously detected in feces, leading to significantly lower serum uric acid levels and confirming its potential as a therapeutic adjunct agent in treating hyperuricemia.

GUT MICROBES (2021)

Article Biochemistry & Molecular Biology

Chlorogenic acid inhibits trimethylamine-N-oxide formation and remodels intestinal microbiota to alleviate liver dysfunction in high l-carnitine feeding mice

Xiangnan Zhang et al.

Summary: The study demonstrates that chlorogenic acid (CGA) can inhibit the formation of trimethylamine-N-oxide (TMAO) induced by high l-carnitine ingestion, thereby preventing liver injury in mice. CGA not only improves the structure of gut microbiota but also alleviates liver dysfunction and inflammatory response.

FOOD & FUNCTION (2021)

Article Biochemistry & Molecular Biology

Chlorogenic acid supplementation ameliorates hyperuricemia, relieves renal inflammation, and modulates intestinal homeostasis

Xiaofei Zhou et al.

Summary: Chlorogenic acid (CGA) has protective effects on mice with hyperuricemia (HUA), reducing levels of uric acid and inflammatory markers, and increasing the production of fecal short-chain fatty acids to maintain intestinal function. Additionally, CGA treatment alters the gut microbiota composition and metabolism, potentially offering a therapeutic approach for HUA and associated inflammatory responses.

FOOD & FUNCTION (2021)

Article Urology & Nephrology

The case for uric acid-lowering treatment in patients with hyperuricaemia and CKD

Yuka Sato et al.

NATURE REVIEWS NEPHROLOGY (2019)

Article Biochemistry & Molecular Biology

Chlorogenic Acid Improves the Regorafenib Effects in Human Hepatocellular Carcinoma Cells

Maria Grazia Refolo et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Urology & Nephrology

Inflammation in AKI: Current Understanding, Key Questions, and Knowledge Gaps

Hamid Rabb et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2016)

Review Urology & Nephrology

Gut microbiota in renal physiology: focus on short-chain fatty acids and their receptors

Jennifer L. Pluznick

KIDNEY INTERNATIONAL (2016)

Article Multidisciplinary Sciences

Intestinal Microbiota Distinguish Gout Patients from Healthy Humans

Zhuang Guo et al.

SCIENTIFIC REPORTS (2016)

Review Microbiology

Microbiology Meets Big Data: The Case of Gut Microbiota-Derived Trimethylamine

Gwen Falony et al.

ANNUAL REVIEW OF MICROBIOLOGY, VOL 69 (2015)

Article Urology & Nephrology

EGF Receptor Inhibition Alleviates Hyperuricemic Nephropathy

Na Liu et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2015)

Review Medical Laboratory Technology

Therapeutic targets for treating fibrotic kidney diseases

So-Young Lee et al.

TRANSLATIONAL RESEARCH (2015)

Article Biochemistry & Molecular Biology

Oxidative stress and autophagy: Crucial modulators of kidney injury

Angara Sureshbabu et al.

REDOX BIOLOGY (2015)

Article Multidisciplinary Sciences

Gut-Microbiota-Metabolite Axis in Early Renal Function Decline

Clara Barrios et al.

PLOS ONE (2015)

Article Urology & Nephrology

The Gut as a Source of Inflammation in Chronic Kidney Disease

Wei Ling Lau et al.

NEPHRON (2015)

Article Microbiology

Molecular Epidemiology of Enterococcal Bacteremia in Australia

Geoffrey W. Coombs et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2014)

Review Urology & Nephrology

Uric Acid as a Target of Therapy in CKD

Diana I. Jalal et al.

AMERICAN JOURNAL OF KIDNEY DISEASES (2013)

Article Biochemistry & Molecular Biology

Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis

Robert A. Koeth et al.

NATURE MEDICINE (2013)

Review Cell Biology

PI3K signalling: the path to discovery and understanding

Bart Vanhaesebroeck et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)

Article Medicine, General & Internal

Gout

Pascal Richette et al.

LANCET (2010)

Article Urology & Nephrology

A role for uric acid in the progression of renal disease

DH Kang et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2002)