Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 70, Issue 27, Pages 8317-8325Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.2c02836
Keywords
lignin; isotopically labeled 13C lignin; dietary fiber; intestinal metabolism; pig cecum model; gut microbiota; small phenolic metabolites
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This study investigated whether lignin is metabolized by the gut microbiota using the ex vivo pig cecum model. Ten small phenolic lignin degradation products were identified and their quantity was estimated.
A diet with a high dietary fiber content is often recommended in today's nutrition due to several beneficial health effects related to its intake. Lignin as a part of dietary fiber is the second most abundant natural polymer and considered to be stable during digestion. However, some studies indicate a partial degradation during the intestinal metabolism. To further elucidate this hypothesis, the aim of this study was to investigate whether lignin is metabolized by the gut microbiota using the ex vivo pig cecum model. As potential lignin-derived metabolites might already naturally occur in the pig cecal matrix, an approach using isotopically labeled C-13 lignin was chosen for this study. Ten small phenolic lignin degradation products and their time-dependent metabolism were identified via an untargeted HPLC-HRMS approach, and the quantity of the metabolites was estimated. From the results, we conclude that is small metabolites.
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