Journal
JOURNAL OF AFFECTIVE DISORDERS
Volume 310, Issue -, Pages 369-376Publisher
ELSEVIER
DOI: 10.1016/j.jad.2022.04.153
Keywords
Bipolar disorder; Major depressive disorder; MCCB Cognitive function; Prevalence; Characteristics
Categories
Funding
- National Natural Science Foundation of China [81801347, 82071543]
- Planned Science and Technology Project of Guangdong Province, China [2017B020227011]
- Guangdong Basic and Applied Basic Research Foundation, China [2021A1515011034, 2021A1515110130]
- Hunan Province innovation province construction project [2019SK2334]
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This study investigated the prevalence and characteristics of cognitive impairment in patients with bipolar disorder and major depressive disorder. The results showed that both groups had significantly reduced cognitive performance compared to the healthy control group. The cognitive impairments in both groups were clinically significant, but more common in patients with bipolar disorder. These findings suggest the importance of cognitive screening and intervention strategies for patients with mood disorders.
Background: Cognitive impairment has been acknowledged as a core clinical manifestation of bipolar disorder (BD) as well as major depressive disorder (MDD). Determining the prevalence and characteristics of cognitive impairment is important for clinical interventions. This study investigated the prevalence and characteristics of cognitive impairment based on the Measurement and Treatment Research to Improve Cognition Schizophrenia Consensus Cognitive Battery (MCCB) in both BD and MDD.Method: One hundred and forty-nine BD II depression, 147 MDD, and 124 demographically matched healthy controls (HC) underwent MCCB cognitive assessment. The prevalence of MCCB cognitive impairment and group difference comparisons were performed. Additionally, association analysis was performed to investigate the relationship between cognitive performance and clinical variables.Results: Compared to the HC group, both BD II depression and MDD groups had a significantly reduced performance for all MCCB cognitive domains (allp < 0.05). The numerical scores for visual learning were lower in the BD II depression group compared to the MDD group. 32.89% of the BD II depression patients had clinically significant impairment (>1.5 SD below the normal mean) in two or more MCCB domains compared to 23.13% for MDD patients.Conclusions: A high percent of patients in the BD II depression and MDD group exhibited MCCB cognitive impairments with clinical significance. Cognitive impairments were more common in BD II depression patients compared to MDD patients, particularly for visual learning. These findings suggest that clinicians should be aware of the severe cognitive impairment in mood disorders and establish effective cognitive screening and intervention strategies.
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