Journal
JAPANESE JOURNAL OF RADIOLOGY
Volume 40, Issue 11, Pages 1121-1137Publisher
SPRINGER
DOI: 10.1007/s11604-022-01306-w
Keywords
Fever of unknown origin; FUO; FDG-PET; CT; IUO
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This review presents the application of FDG-PET/CT in diagnosing the cause of fever of unknown origin, including diagnostic performance, test protocols, possible factors influencing the diagnostic result, outcomes, and cost-effectiveness.
Numerous studies have clarified the usefulness of F-18-fluorodeoxyglucose (FDG)-PET/CT (positron emission tomography) for diagnosing the cause of fever of unknown origin (FUO). Various types of disease can cause FUO, but the cause remains unknown in a certain proportion of FUO, even when the advanced diagnostic methodologies are used. FDG-PET/CT is regarded as a second-line modality in the diagnostic process of FUO, and its potential to identify the cause of FUO will be maximized when the appropriate clinical considerations are understood. Accordingly, this review presents basic knowledge regarding FUO, and reports the current status of FDG-PET/CT applied to diagnosing the cause of FUO, including diagnostic performance, test protocols, possible factors influencing the diagnostic result, outcomes, and cost-effectiveness. This knowledge will enable effective future use of FDG-PET/CT to improve outcomes in patients with FUO.
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