Impact of Commissural Misalignment on Hydrodynamic Function Following Valve-in-Valve Intervention With the ACURATE neo

BACKGROUND Limited evidence is available regarding valve-in-valve (VIV) intervention with the ACURATE neo transcatheter heart valve (THV). Low implantation has demonstrated leaflet interaction between the surgical bioprosthesis and the THV, leading to impaired hydrodynamic performance. It is unknown if commissural alignment (CA) can affect this phenomenon. Novel techniques have now been developed to achieve CA with the ACURATE neo THV. OBJECTIVES The aim of this study was to assess the impact of commissural misalignment (CMA) on hydrodynamic function following VIV intervention with the ACURATE neo THV using a bench model. METHODS VIV intervention was performed with the ACURATE neo (a self-expanding THV with supra-annular leaflet position) implanted deep in the surgical bioprosthetic aortic valve (Mitroflow). Hydrodynamic function at CA (0 degrees) and 3 different degrees of CMA (30 degrees, 60 degrees, and 90 degrees) was tested. As per the International Organization for Standardization, a regurgitant fraction <20% is considered optimal. RESULTS Following VIV, the central THV regurgitant fraction at 0 degrees, 30 degrees, 60 degrees, and 90 degrees of CMA was 8.6% +/- 2.0%, 30.3% +/- 12.0%, 42.6% +/- 11.9%, and 66.7% +/- 25.4% (P < 0.0001), respectively. On high-speed video there was no evidence of leaflet interaction at CA, whereas at 30 degrees, 60 degrees, and 90 degrees of CMA there was clear evidence of THV leaflet interaction with those of the surgical valve, leading to impaired leaflet closure and to severe central THV regurgitation. CONCLUSIONS In VIV using the ACURATE neo THV at deep implantation, increasing degree of CMA was associated with THV leaflet interaction with those of the surgical valve and worsening regurgitant fraction. THV leaflet interaction was prevented when there was CA. (C) 2022 by the American College of Cardiology Foundation.

Automated summary

This study assessed the impact of commissural misalignment on hydrodynamic function during valve-in-valve intervention with the ACURATE neo transcatheter heart valve. The findings showed that increasing degrees of commissural misalignment were associated with leaflet interaction and worsening regurgitant fraction.