Journal
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
Volume 25, Issue 11, Pages 1324-1327Publisher
WILEY
DOI: 10.1111/1756-185X.14411
Keywords
Covid-19 vaccination; cytological-energy analysis; reactive arthritis; synovial fluid
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Funding
- Krajska zdravotni a. s., Usti nad Labem, Czech Republic [IGA-KZ-217116003]
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This article reports a rare case of synovitis in the knee joint after the first dose of mRNA vaccine. Through comprehensive examination and treatment, the patient eventually made a full recovery.
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the resulting coronavirus 2019 disease (COVID-19) have spread all around the world since 2019 and have affected millions of people. The development of COVID-19 vaccines helped to decelerate the spread of the virus. However, as in the case of vaccines against other infectious diseases, adverse events can also present with COVID-19 vaccines. Case Presentation We report here a rare case of a 53-year-old man with knee-joint synovitis, after the first dose of messenger RNA vaccine, with no fever and a negative COVID-19 reverse transcription polymerase chain reaction test. During a clinical examination the suspicion of pyogenic arthritis was excluded by blood tests and by a complex joint effusion examination, including a microbiological and cytological-energy analysis of the synovial fluid. The treatment received by our patient consisted of 3 doses of dexamethasone administered intravenously over a period of 3 days. All the symptoms improved after this therapy, and in the 3-week follow-up period we recorded full recovery with no consequences. Conclusion Case reports on patients undergoing COVID-19 vaccination should be examined in order to detect rare and long-term side-effects. This is the first report to present the outcomes of an ultrastructural analysis of post-vaccination synovitis.
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