4.5 Review

Establishing a communication and engagement strategy to facilitate the adoption of the adverse outcome pathways in radiation research and regulation

Related references

Note: Only part of the references are listed.
Review Environmental Sciences

Review of the risk of cancer following low and moderate doses of sparsely ionising radiation received in early life in groups with individually estimated doses

Mark P. Little et al.

Summary: Studies show that there is a significant increase in the risk of cancer and benign neoplasms in infants and children who receive low or moderate levels of radiation. The risks are particularly higher in those exposed to radiation in utero or as children, with brain/CNS tumors, thyroid cancer, and leukemia showing particularly large excess relative risks.

ENVIRONMENT INTERNATIONAL (2022)

Editorial Material Biology

Adverse outcome pathway: a path toward better data consolidation and global co-ordination of radiation research

Vinita Chauhan et al.

Summary: The use of Adverse Outcome Pathway (AOP) approach in radiation research is important for assessing the risks of low dose radiation. The Rad/Chem AOP joint topical group aims to advance the use of AOPs by organizing and evaluating mechanistic knowledge, identifying research needs, and developing radiation-relevant case studies.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2022)

Article Biotechnology & Applied Microbiology

Cancer risk following low doses of ionising radiation-Current epidemiological evidence and implications for radiological protection

W. Ruehm et al.

Summary: This paper presents a synthesis of recent epidemiological evidence on radiation-related cancer risks from low-LET radiation doses of the order of 100 mGy. The evidence shows that doses above 100 mGy can cause cancer, and there is growing evidence for risks below 100 mGy.

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2022)

Article Biology

A case example of a radiation-relevant adverse outcome pathway to lung cancer

Vinita Chauhan et al.

Summary: Adverse Outcome Pathways (AOPs) describe how a sequence of key events starting from a molecular initiator can lead to adverse outcomes relevant to risk assessment. This framework helps organize scientific knowledge, identify potential risks, and in this case study, understand the process of lung cancer induction.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2021)

Article Biology

The integration of the adverse outcome pathway framework to radiation risk assessment

Vinita Chauhan et al.

Summary: The paper discusses the concept of Adverse Outcome Pathway (AOP) and its application in the radiation field to facilitate integration of information for radiation risk assessment. Collaborative efforts are needed to systematically vet the vast amount of literature and harness data for incorporation into an AOP-based framework. AOPs can help identify knowledge gaps, coordinate research, and link key events to adverse outcomes in order to refine risk assessment related to radiation exposures.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2021)

Editorial Material Biology

Biologically based models of cancer risk in radiation research

Jan Christian Kaiser et al.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2021)

Article Environmental Sciences

Quantification of an Adverse Outcome Pathway Network by Bayesian Regression and Bayesian Network Modeling

S. Jannicke Moe et al.

Summary: This study presents a method for quantifying adverse outcome pathways (AOPs) using a combination of regression modeling and Bayesian network modeling, demonstrating its feasibility on an experimental data set.

INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT (2021)

Review Biology

Adverse outcome pathways, key events, and radiation risk assessment

R. Julian Preston et al.

Summary: This contribution aims to review and propose approaches for integrating data from radiation biology and epidemiology studies to enhance low-dose health risk assessment. By leveraging the AOP/KE approach, it suggests developing BBDR models for radiation-induced cancers and circulatory diseases. Tight integration of epidemiology data and radiation biology information is considered necessary to improve low-dose radiation risk estimates.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2021)

Editorial Material Biology

Collaborative efforts are needed among the scientific community to advance the adverse outcome pathway concept in areas of radiation risk assessment

Vinita Chauhan et al.

Summary: This paper discusses the importance of consolidating mechanistic research to guide priority research and facilitate radiation risk assessments. Organizing data using the adverse outcome pathway (AOP) framework may improve understanding of radiation knowledge, reduce uncertainties, and benefit the field of radiation research. Collaboration is crucial for effective integration of mechanistic data and supporting radiation risk assessments.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2021)

Article Biology

Bringing together scientific disciplines for collaborative undertakings: a vision for advancing the adverse outcome pathway framework

Vinita Chauhan et al.

Summary: In recent years, the grand OECD AOP program has been gradually applied to risk assessment, with potential importance. NEA's HLG-LDR is also committed to advancing the field through improving research coordination, synergies between radiological and chemical research, etc. Multidisciplinary teams, data management and machine learning tools are considered pathways to progress from weight of evidence to computational causal inference.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2021)

Review Biology

Areas of research to support the system of radiological protection

D. Laurier et al.

Summary: This document presents the ICRP's updated vision on Areas of Research to Support the System of Radiological Protection, aiming to complement research priorities promoted by other relevant international organisations and contribute to the review and revision process of the System of Radiological Protection launched by ICRP, updating the 2007 General Recommendations in ICRP Publication 103.

RADIATION AND ENVIRONMENTAL BIOPHYSICS (2021)

Review Biology

Expert consultation is vital for adverse outcome pathway development: a case example of cardiovascular effects of ionizing radiation

Vinita Chauhan et al.

Summary: This article discusses the use of the AOP approach to investigate the pathways and mechanisms of radiation-induced cardiovascular diseases (CVD) and the importance of expert collaboration in constructing AOPs. Through expert consultation and collaboration, AOP development can be effectively facilitated.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2021)

Article Toxicology

Extracting and Benchmarking Emerging Adverse Outcome Pathway Knowledge

Nathan L. Pollesch et al.

TOXICOLOGICAL SCIENCES (2019)

Article Biology

Why is the multiple stressor concept of relevance to radioecology?

B. Salbu et al.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2019)

Article Biology

Is there a role for the adverse outcome pathway framework to support radiation protection?

Vinita Chauhan et al.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2019)

Article Environmental Sciences

Adverse outcome pathway networks I: Development and applications

Dries Knapen et al.

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY (2018)

Article Environmental Sciences

Population sensitivities of animals to chronic ionizing radiation-model predictions from mice to elephant

Tatiana G. Sazykina

JOURNAL OF ENVIRONMENTAL RADIOACTIVITY (2018)

Article Pharmacology & Pharmacy

AOP-DB: A database resource for the exploration of Adverse Outcome Pathways through integrated association networks

Maureen E. Pittman et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2018)

Article Engineering, Environmental

Quantitative Adverse Outcome Pathways and Their Application to Predictive Toxicology

Rory B. Conolly et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2017)

Article Environmental Sciences

Advancing the Adverse Outcome Pathway Framework-An International Horizon Scanning Approach

Carlie A. LaLone et al.

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY (2017)

Article Toxicology

Adverse outcome pathways: opportunities, limitations and open questions

Marcel Leist et al.

ARCHIVES OF TOXICOLOGY (2017)

Article Medicine, Research & Experimental

The Adverse Outcome Pathway Concept: A Basis for Developing Regulatory Decision-making Tools

Nathalie Delrue et al.

ATLA-ALTERNATIVES TO LABORATORY ANIMALS (2016)

Article Environmental Sciences

Environmental risk assessment of combined effects in aquatic ecotoxicology: A discussion paper

Jonny Beyer et al.

MARINE ENVIRONMENTAL RESEARCH (2014)

Article Toxicology

Adverse Outcome Pathway (AOP) Development I: Strategies and Principles

Daniel L. Villeneuve et al.

TOXICOLOGICAL SCIENCES (2014)

Article International Relations

The perception gap: Radiation and risk

Paul Slovic

BULLETIN OF THE ATOMIC SCIENTISTS (2012)

Article Medicine, Research & Experimental

A Replacement-first Approach to Toxicity Testing is Necessary to Successfully Reauthorize TSCA

Paul A. Locke et al.

ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION (2011)

Article Environmental Sciences

ADVERSE OUTCOME PATHWAYS: A CONCEPTUAL FRAMEWORK TO SUPPORT ECOTOXICOLOGY RESEARCH AND RISK ASSESSMENT

Gerald T. Ankley et al.

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY (2010)

Review Environmental Sciences

TOXICITY TESTING IN THE 21ST CENTURY: A VISION AND A STRATEGY

Daniel Krewski et al.

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS (2010)