Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 624, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.ijpharm.2022.121991
Keywords
Paediatric drug delivery; Chocolate dosage forms; 3D printing; Mold -casting; Patient compliance; Pharmaceutical compounding
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This study aimed to investigate the feasibility of using 3D printing technology to prepare pediatric-friendly personalized dosage forms. The 3D printed dosage forms passed all quality control tests and allowed for precision overdose adjustment, unlike the molded dosage forms prepared using mold-casting. The results suggest that chocolate-based 3D printed dosage forms may serve as a highly acceptable alternative to mold-casting in pharmaceutical compounding.
Pharmaceutical compounding is a core activity in the preparation of patient-specific dosage forms. In the current study we aimed to investigate whether 3D printing could be employed for the preparation of pediatric-friendly personalized dosage forms that fulfil the acceptance criteria specified in the pharmacopoeias for conventional dosage forms. We then compared the 3D printed dosage forms with the same formulations prepared with mold -casting, a method frequently applied during pharmaceutical compounding. The molded dosage forms failed to pass most of the quality control tests, including the mass uniformity and content uniformity tests, as well as dose accuracy, contrary to the 3D printed, which not only passed all tests but also enabled precision overdose adjustment. Hence, 3D printing of chocolate-based dosage forms may effectively serve as an acceptable alter-native method to mold casting in compounding patient-specific medication at the point-of-care.
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