4.7 Article

The effect of dilution of fusidic acid cream and betamethasone dipropionate cream in complex extemporaneous mixes on formulation performance

Journal

INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 624, Issue -, Pages -

Publisher

ELSEVIER
DOI: 10.1016/j.ijpharm.2022.121988

Keywords

Atopic dermatitis; Topical corticosteroid; Emollient; Topical antibiotic; Skin permeation

Funding

  1. University of Hertfordshire

Ask authors/readers for more resources

The Aron regimen is an unconventional therapy for atopic dermatitis that aims to treat the condition and reduce bacterial colonization on the skin. This study investigates the impact of diluting the components of the therapy on formulation performance, and the results show significant reductions in drug flux, absorption, and skin retention compared to marketed products.
The Aron regimen is an unconventional therapy which entails frequent applications of an extemporaneously prepared three component system (a topical antibiotic, a corticosteroid and an emollient), with the intention of decolonising the skin of S. aureus whilst treating atopic dermatitis. The impact of heavily diluting these topical medicinal products, to differing extents, on formulation performance is not well understood thus was investigated in this study. Following a single application of a range of compounded Aron mixes (fusidic acid and betamethasone dipropionate diluted to varying extents in an emollient base), significant reductions in the expected drug flux across silicone membrane, ex vivo percutaneous absorption and skin retention of both drugs relative to the marketed products were observed. This was attributed to a number of complex formulation effects making such changes difficult to predict in a clinical setting. Further investigations are required to evaluate the impact of frequent applications of the Aron mix to widespread areas on clinical efficacy, antimicrobial resistance and long term side effects.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available