Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 13, Pages -Publisher
MDPI
DOI: 10.3390/ijms23137071
Keywords
rheumatoid arthritis; angiogenesis; molecular imaging; PET; SPECT; scintigraphy; hybrid imaging
Funding
- European Union [847551]
- Marie Curie Actions (MSCA) [847551] Funding Source: Marie Curie Actions (MSCA)
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Extensive angiogenesis in rheumatoid arthritis is a crucial event in the development of proliferative synovium and can be influenced by disease duration, activity, severity, and inflammatory cell infiltration. Nuclear imaging modalities are valuable tools for accurately tracking molecular changes in angiogenesis in multiple joints simultaneously.
Extensive angiogenesis is a characteristic feature in the synovial tissue of rheumatoid arthritis (RA) from a very early stage of the disease onward and constitutes a crucial event for the development of the proliferative synovium. This process is markedly intensified in patients with prolonged disease duration, high disease activity, disease severity, and significant inflammatory cell infiltration. Angiogenesis is therefore an interesting target for the development of new therapeutic approaches as well as disease monitoring strategies in RA. To this end, nuclear imaging modalities represent valuable non-invasive tools that can selectively target molecular markers of angiogenesis and accurately and quantitatively track molecular changes in multiple joints simultaneously. This systematic review summarizes the imaging markers used for single photon emission computed tomography (SPECT) and/or positron emission tomography (PET) approaches, targeting pathways and mediators involved in synovial neo-angiogenesis in RA.
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