Role of Vitamin D in Liver Disease and Complications of Advanced Chronic Liver Disease

Vitamin D is a crucial nutrient with many pleiotropic effects on health and various chronic diseases. The purpose of this review is to provide a detailed report on the pathophysiological mechanisms underlying vitamin D deficiency in patients with chronic liver disease, addressing the different liver etiologies and the condition of advanced chronic liver disease (cirrhosis) with related complications. To date, patients with liver disease, regardless of underlying etiology, have been shown to have reduced levels of vitamin D. There is also evidence of the predictive role of vitamin D values in complications and progression of advanced disease. However, specific indications of vitamin D supplementation are not conclusive concerning what is already recommended in the general population. Future studies should make an effort to unify and validate the role of vitamin D supplementation in chronic liver disease.

Automated summary

This review provides a detailed report on the pathophysiological mechanisms underlying vitamin D deficiency in patients with chronic liver disease. It discusses the different liver etiologies and the condition of advanced chronic liver disease with related complications. It is found that patients with liver disease have reduced levels of vitamin D, regardless of the underlying etiology. There is evidence suggesting that vitamin D levels have a predictive role in complications and progression of advanced disease. However, specific indications of vitamin D supplementation in chronic liver disease are not conclusive and further studies are needed.