Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/ijms23126698
Keywords
diverticular disease; SUDD; pathophysiology; genetic factors; environment; diet; microbiota; inflammation; ENS
Funding
- Italian Ministry of Education, University and Research
- University of Bologna
- Fondazione del Monte di Bologna e Ravenna
- Fondazione Carisbo, Bologna, Italy
- Italian Ministry of Health [GR-2018-12367062]
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Diverticular disease is a common clinical problem, with most cases being asymptomatic. However, around 25% of patients develop symptoms. The pathophysiology of diverticular disease and its clinical manifestations are still not fully understood.
Diverticular disease is a common clinical problem, particularly in industrialized countries. In most cases, colonic diverticula remain asymptomatic throughout life and sometimes are found incidentally during colonic imaging in colorectal cancer screening programs in otherwise healthy subjects. Nonetheless, roughly 25% of patients bearing colonic diverticula develop clinical manifestations. Abdominal symptoms associated with diverticula in the absence of inflammation or complications are termed symptomatic uncomplicated diverticular disease (SUDD). The pathophysiology of diverticular disease as well as the mechanisms involved in the shift from an asymptomatic condition to a symptomatic one is still poorly understood. It is accepted that both genetic factors and environment, as well as intestinal microenvironment alterations, have a role in diverticula development and in the different phenotypic expressions of diverticular disease. In the present review, we will summarize the up-to-date knowledge on the pathophysiology of diverticula and their different clinical setting, including diverticulosis and SUDD.
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