Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 15, Pages -Publisher
MDPI
DOI: 10.3390/ijms23158554
Keywords
phage display; inflammation target; anti-inflammatory peptides; therapeutic peptide; inflammation pathway
Funding
- National Key R&D Program of China [2018YFB1304702]
- National Natural Science Foundation of China [31970423, 32071242]
- Nature Science Foundation of Sichuan Province [2022NSFSC0579]
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This review discusses the regular process of using phage display technology to screen therapeutic peptides and the peptides that have been screened for their anti-inflammatory properties in recent years. The article describes how these peptides were screened and their in vitro and in vivo effects. It also explores the current challenges and future outlook of using phage display to obtain anti-inflammatory therapeutic peptides.
For the treatment of inflammatory illnesses such as rheumatoid arthritis and carditis, as well as cancer, several anti-inflammatory medications have been created over the years to lower the concentrations of inflammatory mediators in the body. Peptides are a class of medication with the advantages of weak immunogenicity and strong activity, and the phage display technique is an effective method for screening various therapeutic peptides, with a high affinity and selectivity, including anti-inflammation peptides. It enables the selection of high-affinity target-binding peptides from a complex pool of billions of peptides displayed on phages in a combinatorial library. In this review, we will discuss the regular process of using phage display technology to screen therapeutic peptides, and the peptides screened for anti-inflammation properties in recent years according to the target. We will describe how these peptides were screened and how they worked in vitro and in vivo. We will also discuss the current challenges and future outlook of using phage display to obtain anti-inflammatory therapeutic peptides.
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