4.7 Review

Recent Advances in Renal Medullary Carcinoma

Related references

Note: Only part of the references are listed.
Review Oncology

Clinical Review on the Management of Metastatic Renal Cell Carcinoma

Jennifer Tran et al.

Summary: Renal cell carcinomas show significant variations in tumor biology and disease progression, resulting in diverse treatment paradigms. Combination therapies have become the standard of care for most patients with metastatic renal cell carcinoma. This review highlights recent crucial data that have led to changes in treatment approaches and provides a practical framework for managing patients with mRCC.

JCO ONCOLOGY PRACTICE (2022)

Article Biotechnology & Applied Microbiology

Haplotype-resolved assembly of diploid genomes without parental data

Haoyu Cheng et al.

Summary: This paper presents an algorithm that combines PacBio HiFi reads and Hi-C chromatin interaction data to achieve haplotype-resolved genome assembly from single samples without the need for parent sequencing. The algorithm outperforms existing single-sample assembly pipelines and produces assemblies of similar quality to the best pedigree-based assemblies when applied to human and other vertebrate samples.

NATURE BIOTECHNOLOGY (2022)

Article Multidisciplinary Sciences

The complete sequence of a human genome

Sergey Nurk et al.

Summary: The Telomere-to-Telomere (T2T) Consortium has presented a complete sequence of a human genome, T2T-CHM13, which covers the whole genome except for the Y chromosome. This new sequence includes gapless assemblies, error corrections in previous references, and nearly 200 million base pairs of additional sequence with gene predictions, including protein coding genes. The completion of important regions allows for further studies on genetic variations and functions.

SCIENCE (2022)

Review Medical Laboratory Technology

The Differential Diagnosis of Medullary-Based Renal Masses

Nicholas Baniak et al.

Summary: This article provides an overview of medullary-based renal tumors and other tumors with similar morphology and growth patterns, emphasizing the importance of accurate diagnosis for appropriate surgical and clinical management.

ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE (2021)

Review Medicine, General & Internal

Renal cell carcinoma in children and adolescents

Min He et al.

Summary: Renal cell carcinomas (RCCs) are rare in children and adolescents, posing challenges in treatment approach. The translocation type of RCC, predominant in children and adolescents, is rarely diagnosed in adults. More data is needed to determine the applicability of current therapies in the pediatric population.

MEDICINE (2021)

Review Oncology

Progress Update in Pediatric Renal Tumors

Juhi Jain et al.

Summary: Recent clinical trials have made significant improvements in the care of children with pediatric tumors, particularly in standardizing treatment for rare cancers such as bilateral Wilms tumor. While there have been improvements in event free and overall survival for many pediatric renal tumors in recent trials, there are still subsets of rarer cancers with poor outcomes that require new therapeutic strategies. Future trials aim to balance treatment toxicity and efficacy for those with good outcomes while exploring novel therapeutics for those with poor outcomes.

CURRENT ONCOLOGY REPORTS (2021)

Article Oncology

Transposable element insertion as a mechanism of SMARCB1 inactivation in atypical teratoid/rhabdoid tumor

Christian Thomas et al.

Summary: AT/RT is a malignant brain tumor predominantly occurring in infants, caused by SMARCB1 mutations, with some cases lacking biallelic mutations. A case report found SMARCB1 loss due to Alu element insertion resulting in frame-shift truncation, a mechanism not widely recognized in AT/RT.

GENES CHROMOSOMES & CANCER (2021)

Review Pathology

ALK-rearranged Renal Cell Carcinoma (RCC): A Report of 2 Cases and Review of the Literature Emphasizing the Distinction Between VCL-ALK and Non-VCL-ALK RCC

Sintawat Wangsiricharoen et al.

Summary: ALK rearrangement-associated renal cell carcinoma (ALK-rearranged RCC) is a new provisional entity in the 2016 World Health Organization classification of RCCs. This study reports 2 cases of ALK-rearranged RCC, one with a VCL-ALK fusion and the other with an EML4-ALK fusion, showing distinct features.

INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY (2021)

Article Oncology

Association of High-Intensity Exercise with Renal Medullary Carcinoma in Individuals with Sickle Cell Trait: Clinical Observations and Experimental Animal Studies

Daniel D. Shapiro et al.

Summary: Renal medullary carcinoma (RMC) is a rare and highly aggressive malignancy that affects individuals of African descent with sickle cell trait (SCT). Although modifiable risk factors for RMC have not been identified, high-intensity exercise may be associated with the development of RMC in individuals with SCT.

CANCERS (2021)

Article Oncology

Comprehensive genomic profiling of metastatic collecting duct carcinoma, renal medullary carcinoma, and clear cell renal cell carcinoma

Gennady Bratslavsky et al.

Summary: The study found that genomic alteration patterns in collecting duct carcinoma (CDC) and renal medullary carcinoma (RMC) differ significantly from clear cell renal cell carcinoma (CCRCC). Targeted therapies for CDC and RMC appear limited, with rare opportunities to target alterations in receptor tyrosine kinase and MTOR pathways. Similarly, the low TMB and absence of MSI-High status in CDC and RMC suggest resistance to immunotherapies.

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2021)

Article Pediatrics

Childhood Clear Cell Sarcoma of Kidney: Incidence and Survival

Hui Gao et al.

Summary: The incidence of CCSK remains stable over the years with an age-adjusted rate of 0.205 per million in children, with boys and age under 4 being risk factors. The 5-year overall survival rate for CCSK is 87%, but when compared to WT and well-balanced, CCSK shows a significantly poorer outcome.

FRONTIERS IN PEDIATRICS (2021)

Article Oncology

Efficacy and Safety of Bevacizumab Plus Erlotinib in Patients with Renal Medullary Carcinoma

Andrew J. Wiele et al.

Summary: Bevacizumab plus erlotinib has been shown to be safe and effective in treating RMC patients, with two patients achieving partial response, seven patients achieving stable disease, and overall tumor burden reduction in seven out of ten patients. Additionally, the treatment showed good tolerability with no severe adverse events.

CANCERS (2021)

Article Oncology

Novel Patient Metastatic Pleural Effusion-Derived Xenograft Model of Renal Medullary Carcinoma Demonstrates Therapeutic Efficacy of Sunitinib

Alex Q. Lee et al.

Summary: A metastatic PE-derived RMC PDX model was successfully established, maintaining histologic features of the patient cancer. Molecular integrity was well maintained between renal tumor and PE PDXs, as well as between two generations of renal tumor PDXs. Sunitinib demonstrated therapeutic efficacy for RMC using the PE PDX model.

FRONTIERS IN ONCOLOGY (2021)

Article Oncology

Combination Therapy With Bortezomib in Renal Medullary Carcinoma: A Case Series

Alixandra Ryan et al.

Summary: Renal medullary carcinoma is a rare and aggressive neoplasm, with a high mortality rate within months. A perioperative regimen of platinum-based therapy, doxorubicin, and bortezomib led to complete responses in three patients, with long-lasting remissions. A multi-institution clinical trial may be warranted for further research.

CLINICAL GENITOURINARY CANCER (2021)

Article Genetics & Heredity

Haplotype-resolved germline and somatic alterations in renal medullary carcinomas

Kar-Tong Tan et al.

Summary: The haplotype of the sickle cell mutation in RMC patients originates from three geographical regions in Africa, with the sickle cell mutation being identified as the sole candidate variant for high risk. Additionally, SMARCB1 structural variants in RMC are characterized by blunt or 1-bp homology events.

GENOME MEDICINE (2021)

Article Oncology

Case Analysis of 14 Children with Malignant Rhabdoid Tumor of the Kidney

Jing Li et al.

Summary: The study aimed to summarize the clinical features and prognoses of malignant rhabdoid tumor of the kidney (MRTK) in children, and analyze high-risk factors affecting MRTK prognosis. The most common site for MRTK distant metastases was found to be in the lungs, with poor prognoses associated with factors such as age less than 24 months, Ki 67 > 70%, and the presence of distant metastases.

CANCER MANAGEMENT AND RESEARCH (2021)

Review Oncology

Characteristics and Treatment Challenges of Non-Clear Cell Renal Cell Carcinoma

Pierangela Sepe et al.

Summary: Non-clear cell renal cell carcinomas (ncRCC) are rare and lack standard treatments, with choices based on extrapolating results from clear cell RCC trials; the emergence of immunotherapy and new targeted drugs provides more diverse treatment options for the future.

CANCERS (2021)

Article Urology & Nephrology

Renal medullary carcinoma masquerading as renal infection: a case report

Zhong-Ming Huang et al.

BMC NEPHROLOGY (2020)

Editorial Material Radiology, Nuclear Medicine & Medical Imaging

Renal Medullary Carcinoma on Dual-Time Point FDG PET/CT Imaging

Guozhu Hou et al.

CLINICAL NUCLEAR MEDICINE (2020)

Article Oncology

Molecular hallmarks of renal medullary carcinoma: more to c-MYC than meets the eye

Pavlos Msaouel et al.

MOLECULAR & CELLULAR ONCOLOGY (2020)

Article Biochemistry & Molecular Biology

Resolving the full spectrum of human genome variation using Linked-Reads

Patrick Marks et al.

GENOME RESEARCH (2019)

Article Oncology

Clonally Expanded T Cells Reveal Immunogenicity of Rhabdoid Tumors

Amaury Leruste et al.

CANCER CELL (2019)

Article Urology & Nephrology

Renal Medullary Carcinoma: a Report of the Current Literature

Leandro Blas et al.

CURRENT UROLOGY REPORTS (2019)

Review Urology & Nephrology

Atypical presentation of renal medullary carcinoma: A case report and review of the literature

Ali AL-Daghmin et al.

UROLOGY CASE REPORTS (2019)

Review Pathology

SMARCB1-deficient Tumors of Childhood: A Practical Guide

Bruce R. Pawel

PEDIATRIC AND DEVELOPMENTAL PATHOLOGY (2018)

Article Oncology

Renal medullary carcinoma: A national analysis of 159 patients

Brian Ezekian et al.

PEDIATRIC BLOOD & CANCER (2017)

Article Oncology

Predictive role of PD-L1 expression in the response of renal Medullary carcinoma to PD-1 inhibition

Quaovi Sodji et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2017)

Review Oncology

Renal Medullary Carcinoma: Establishing Standards in Practice

Kathryn E. Beckermann et al.

JOURNAL OF ONCOLOGY PRACTICE (2017)

Article Oncology

Genomic Characterization of Renal Medullary Carcinoma and Treatment Outcomes

Maria I. Carlo et al.

CLINICAL GENITOURINARY CANCER (2017)

Article Urology & Nephrology

Renal medullary carcinoma with an ophthalmic metastasis

Christine Ibilibor et al.

UROLOGY ANNALS (2017)

Article Urology & Nephrology

Renal cell cancer histological subtype distribution differs by race and sex

Loren Lipworth et al.

BJU INTERNATIONAL (2016)

Article Oncology

ALK-rearranged renal cell carcinomas in children

Mariana M. Cajaiba et al.

GENES CHROMOSOMES & CANCER (2016)

Article Biotechnology & Applied Microbiology

Haplotyping germline and cancer genomes with high-throughput linked-read sequencing

Grace X. Y. Zheng et al.

NATURE BIOTECHNOLOGY (2016)

Editorial Material Pathology

Collecting Duct Carcinoma Versus Renal Medullary Carcinoma An Appeal for Nosologic and Biological Clarity

Mahul B. Amin et al.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2014)

Review Genetics & Heredity

A rationale to target the SWI/SNF complex for cancer therapy

Anja F. Hohmann et al.

TRENDS IN GENETICS (2014)

Article Pathology

Renal Medullary Carcinoma Molecular, Immunohistochemistry, and Morphologic Correlation

Qingyan Liu et al.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2013)

Article Multidisciplinary Sciences

Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2

Sarah K. Knutson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Oncology

Renal medullary carcinoma response to chemotherapy: a referral center experience in Brazil

Marina Cavalcanti Maroja Silvino et al.

RARE TUMORS (2013)

Article Cell Biology

SMARCB1/INI1 inactivation in renal medullary carcinoma

Julien Calderaro et al.

HISTOPATHOLOGY (2012)

Article Medicine, Research & Experimental

A remarkably simple genome underlies highly malignant pediatric rhabdoid cancers

Ryan S. Lee et al.

JOURNAL OF CLINICAL INVESTIGATION (2012)

Article Dermatology

Renal Medullary Carcinoma Metastatic to the Scalp

Ryan P. Johnson et al.

AMERICAN JOURNAL OF DERMATOPATHOLOGY (2011)

Article Pathology

INI1-Deficient Tumors: Diagnostic Features and Molecular Genetics

Travis J. Hollmann et al.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2011)

Article Oncology

ALK Rearrangement in Sickle Cell Trait-Associated Renal Medullary Carcinoma

Adrian Marino-Enriquez et al.

GENES CHROMOSOMES & CANCER (2011)

Article Oncology

Response to radiation in renal medullary carcinoma

Alexandra M. Walsh et al.

RARE TUMORS (2011)

Review Oncology

SWI/SNF nucleosome remodellers and cancer

Boris G. Wilson et al.

NATURE REVIEWS CANCER (2011)

Review Oncology

Epidemiology of childhood cancer

Peter Kaatsch

CANCER TREATMENT REVIEWS (2010)

Article Mathematics, Interdisciplinary Applications

The National Wilms Tumor Study: a 40 year perspective

Giulio J. D'Angio

LIFETIME DATA ANALYSIS (2007)

Article Pathology

Renal medullary carcinoma: report of seven cases from Brazil

Isabela C. Watanabe et al.

MODERN PATHOLOGY (2007)

Article Oncology

Significant responses to platinum-based chemotherapy in renal medullary carcinoma

JJ Strouse et al.

PEDIATRIC BLOOD & CANCER (2005)

Article Ophthalmology

Renal medullary carcinoma metastatic to the orbit: A clinicopathologic report

LA Zdinak et al.

OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY (2004)