Correlative Light and Electron Microscopy Using Frozen Section Obtained Using Cryo-Ultramicrotomy (vol 22, 4273, 2021)

Summary: Researchers have developed a new method by combining light and electron microscopy with immunolabeling, to overcome technical barriers in immuno-electron microscopy. This method allows for excellent antigenicity of target proteins and preservation of ultrastructure, without the need for specifically designed correlative light and electron microscopy devices. It can be easily applied in many biomedical studies.