Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 15, Pages -Publisher
MDPI
DOI: 10.3390/ijms23158164
Keywords
hepatocellular carcinoma; NAFLD; hepatitis B; hepatitis C; alcoholic liver disease; single cell
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This article explores the inflammatory implications of the microbiome on pathways leading to hepatocellular carcinoma (HCC), emphasizing how an understanding of these underlying inflammatory principles can lead to a more holistic understanding of the disease, as well as potential therapeutic implications.
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. It is well known that repeated inflammatory insults in the liver can cause hepatic cellular injury that lead to cirrhosis and, ultimately, hepatocellular carcinoma. Furthermore, the microbiome has been implicated in multiple inflammatory conditions which predispose patients to malignancy. With this in mind, we explore the inflammatory implications of the microbiome on pathways that lead to HCC. We also focus on how an understanding of these underlying inflammatory principles lead to a more wholistic understanding of this deadly disease, as well as potential therapeutic implications.
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