Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/ijms23126585
Keywords
inflammation; P2X receptor; thrombosis; platelets; stroke; Alzheimer's disease; Parkinson's disease
Funding
- DZHK (German Research Centre for Cardiovascular Research), partner site Hamburg/Lubeck/Kiel (STO Projekt) [F280404]
- German Research Council (Deutsche Forschungsgemeinschaft, DFG) [SFB/Transregio 240]
- Clinician Scientist Program of the DZHK (German Research Centre for Cardiovascular Research), partner site Hamburg/Lubeck/Kiel
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P2X receptors are a family of cation channel proteins that respond to extracellular ATP. Recent research suggests that targeting purinergic receptors may provide a novel therapeutic approach for neurological diseases. This review explores the role of platelets and purinergic signaling in these conditions.
P2X receptors belong to a family of cation channel proteins, which respond to extracellular adenosine 50 -triphosphate (ATP). These receptors have gained increasing attention in basic and translational research, as they are central to a variety of important pathophysiological processes such as the modulation of cardiovascular physiology, mediation of nociception, platelet and macrophage activation, or neuronal-glial integration. While P2X1 receptor activation is long known to drive platelet aggregation, P2X7 receptor antagonists have recently been reported to inhibit platelet activation. Considering the role of both P2X receptors and platelet-mediated inflammation in neuronal diseases such as multiple sclerosis, Alzheimer's disease, Parkinson's disease, and stroke, targeting purinergic receptors may provide a valuable novel therapeutic approach in these diseases. Therefore, the present review illuminates the role of platelets and purinergic signaling in these neurological conditions to evaluate potential translational implications.
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