Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 14, Pages -Publisher
MDPI
DOI: 10.3390/ijms23147837
Keywords
platelet-derived extracellular vesicles; thrombosis; immune mediated
Funding
- Office of Research and Development and Department of Veterans Affairs [I01CX001932]
- National Institutes of Health [T32 HL007344]
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This review article provides information on the important roles of platelet-derived extracellular vesicles (PEVs) in hemostasis and thrombosis, including their production mechanisms, characteristics, cellular interactions, and pathological role in diseases. The article also highlights the mechanisms through which PEVs can activate parent cells in a feedback loop.
Platelet-derived extracellular vesicles (PEVs) play important roles in hemostasis and thrombosis. There are three major types of PEVs described based on their size and characteristics, but newer types may continue to emerge owing to the ongoing improvement in the methodologies and terms used to define various types of EVs. As the literature on EVs is growing, there are continuing attempts to standardize protocols for EV isolation and reach consensus in the field. This review provides information on mechanisms of PEV production, characteristics, cellular interaction, and their pathological role, especially in autoimmune and infectious diseases. We also highlight the mechanisms through which PEVs can activate parent cells in a feedback loop.
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