4.7 Article

Deubiquitinating Enzyme USP7 Is Required for Self-Renewal and Multipotency of Human Bone Marrow-Derived Mesenchymal Stromal Cells

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

TLR4 downregulation by the RNA-binding protein PUM1 alleviates cellular aging and osteoarthritis

Dong Suk Yoon et al.

Summary: This study found that PUM1 is associated with the self-renewal capacity and aging process of human mesenchymal stem cells (MSC). PUM1 acts by suppressing TLR4-mediated NF-kappa B activity to protect MSCs against cellular senescence and inflammation. Furthermore, the PUM1-TLR4 regulatory axis represents a potential therapeutic target for osteoarthritis.

CELL DEATH AND DIFFERENTIATION (2022)

Article Cell & Tissue Engineering

The RNA-binding protein Musashi2 governs osteoblast-adipocyte lineage commitment by suppressing PPARγ signaling

Jinlong Suo et al.

Summary: Osteoporosis caused by aging is characterized by reduced bone mass and accumulated adipocytes in the bone marrow cavity. The RNA-binding protein Musashi2 (Msi2) regulates the lineage commitment of bone marrow mesenchymal stem cells (BMSCs). Msi2 deficiency leads to increased adipocyte commitment, resulting in decreased bone mass and accumulation of marrow adipocytes.

BONE RESEARCH (2022)

Article Biotechnology & Applied Microbiology

Effective Label-Free Sorting of Multipotent Mesenchymal Stem Cells from Clinical Bone Marrow Samples

Silvia Zia et al.

Summary: This study investigated a new separative technology to isolate mesenchymal stem cells (MSC) from bone marrow (BM), which separates cells based solely on their physical characteristics. The technology allowed real-time visualization and identified multipotent MSCs with higher differentiation potential. It also effectively removed dead cells and unwanted cells while preserving the native characteristics of the cells.

BIOENGINEERING-BASEL (2022)

Article Cell Biology

Enhanced Osteogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells by a Hybrid Hydroxylapatite/Collagen Scaffold

Elisa Mazzoni et al.

Summary: Human bone marrow-derived mesenchymal stem cells (hBMSCs) and their derivative enhanced green fluorescent protein (eGFP)-hBMSCs were used to evaluate an innovative hybrid scaffold composed of granular hydroxylapatite and collagen hemostat. The scaffold supported cell growth, metabolism, and osteogenic differentiation, indicating its potential for bone repair and tissue engineering applications.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Endocrinology & Metabolism

USP7 regulates the proliferation and differentiation of ATDC5 cells through the Sox9-PTHrP-PTH1R axis

Xiaofei Dong et al.

Summary: The study demonstrated that USP7 modulates the proliferation and differentiation of ATDC5 cells via the Sox9-PTHrP-PTH1R axis, with knockdown or inhibition of USP7 suppressing cell proliferation and chondrogenic differentiation while improving hypertrophic differentiation. Additionally, USP7 was found to interact with Sox9 and promote PTHrP expression through binding.
Article Cell Biology

Ubiquitin-specific protease 53 promotes osteogenic differentiation of human bone marrow-derived mesenchymal stem cells

Dawoon Baek et al.

Summary: The study revealed that overexpression of USP53 can enhance osteogenic differentiation of hBMSCs by promoting the degradation of β-catenin through interaction with FBXO31, potentially promoting bone regeneration. Therefore, USP53 may be a promising target for gene therapy in bone regeneration.

CELL DEATH & DISEASE (2021)

Article Biochemistry & Molecular Biology

Different Stages of Quiescence, Senescence, and Cell Stress Identified by Molecular Algorithm Based on the Expression of Ki67, RPS6, and Beta-Galactosidase Activity

Nicola Alessio et al.

Summary: Cells can transition between different states such as quiescence, differentiation, and senescence, with the expression of Ki67, RPS6, and beta-galactosidase used to identify these changes. The study found that cells may go through different stages during the process of entering and leaving quiescence, and that there are early and late stages in the progression towards senescence.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Pharmacology & Pharmacy

Targeting Ubiquitin-Specific Protease 7 (USP7) in Cancer: A New Insight to Overcome Drug Resistance

Jiabin Lu et al.

Summary: Chemoresistance is a major challenge in tumor treatment, requiring further research on the mechanisms of tumor resistance. Deubiquitinases play a crucial role in preventing protein degradation and could be a potential target to overcome drug resistance in cancer therapies.

FRONTIERS IN PHARMACOLOGY (2021)

Review Cell Biology

Senescence in Mesenchymal Stem Cells: Functional Alterations, Molecular Mechanisms, and Rejuvenation Strategies

Jing Liu et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Article Multidisciplinary Sciences

Bach1 regulates self-renewal and impedes mesendodermal differentiation of human embryonic stem cells

Xiangxiang Wei et al.

SCIENCE ADVANCES (2019)

Article Genetics & Heredity

USP7: Structure, substrate specificity, and inhibition

Alexandra Pozhidaeva et al.

DNA REPAIR (2019)

Review Pharmacology & Pharmacy

USP7: Novel Drug Target in Cancer Therapy

Zhiru Wang et al.

FRONTIERS IN PHARMACOLOGY (2019)

Editorial Material Medicine, General & Internal

How Stem Cells Turn into Bone and Fat

Arjun Deb

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Review Cell & Tissue Engineering

Mesenchymal stem cell perspective: cell biology to clinical progress

Mark F. Pittenger et al.

NPJ REGENERATIVE MEDICINE (2019)

Review Chemistry, Medicinal

USP7: Target Validation and Drug Discovery for Cancer Therapy

Jin Zhou et al.

MEDICINAL CHEMISTRY (2018)

Article Multidisciplinary Sciences

Insights into the ubiquitin-proteasome system of human embryonic stem cells

Isabel Saez et al.

SCIENTIFIC REPORTS (2018)

Review Biochemistry & Molecular Biology

Emerging insights into HAUSP (USP7) in physiology, cancer and other diseases

Seemana Bhattacharya et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2018)

Review Biochemical Research Methods

Isolation, cultivation, and characterization of human mesenchymal stem cells

Dolly Mushahary et al.

CYTOMETRY PART A (2018)

Review Cell & Tissue Engineering

Concise Review: Fate Determination of Stem Cells by Deubiquitinating Enzymes

Arun Pandian Chandrasekaran et al.

STEM CELLS (2017)

Article Multidisciplinary Sciences

Molecular basis of USP7 inhibition by selective small-molecule inhibitors

Andrew P. Turnbull et al.

NATURE (2017)

Article Cell & Tissue Engineering

Protein deubiquitinase USP7 is required for osteogenic differentiation of human adipose-derived stem cells

Yiman Tang et al.

STEM CELL RESEARCH & THERAPY (2017)

Review Biochemistry & Molecular Biology

Regulation of pluripotency and differentiation by deubiquitinating enzymes

B. Suresh et al.

CELL DEATH AND DIFFERENTIATION (2016)

Review Cell & Tissue Engineering

Clinical Trials With Mesenchymal Stem Cells: An Update

Tiziana Squillaro et al.

CELL TRANSPLANTATION (2016)

Review Cell Biology

Effects of Oxidative Stress on Mesenchymal Stem Cell Biology

Ryan A. Denu et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)

Review Biochemistry & Molecular Biology

The emerging role of deubiquitinating enzymes in genomic integrity, diseases, and therapeutics

Mingjing He et al.

CELL AND BIOSCIENCE (2016)

Review Cell & Tissue Engineering

The effect of low-frequency electromagnetic field on human bone marrow stem/progenitor cell differentiation

Christina L. Ross et al.

STEM CELL RESEARCH (2015)

Article Cell & Tissue Engineering

microRNA-495 Inhibits Chondrogenic Differentiation in Human Mesenchymal Stem Cells by Targeting Sox9

Seulgi Lee et al.

STEM CELLS AND DEVELOPMENT (2014)

Review Biochemistry & Molecular Biology

Regulation and Cellular Roles of Ubiquitin-Specific Deubiquitinating Enzymes

Francisca E. Reyes-Turcu et al.

ANNUAL REVIEW OF BIOCHEMISTRY (2009)

Review Urology & Nephrology

Protein degradation by the ubiquitin-proteasome pathway in normal and disease states

Stewart H. Lecker et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2006)

Article Endocrinology & Metabolism

Adipogenic differentiation of human adult stem cells from bone marrow stroma (MSCs)

I Sekiya et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2004)

Article Biochemistry & Molecular Biology

Common regulation of growth arrest and differentiation of osteoblasts by helix-loop-helix factors

N Funato et al.

MOLECULAR AND CELLULAR BIOLOGY (2001)