Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/ijms23126616
Keywords
Piezo1; myogenesis; Yoda1; myoblasts; satellite cells; myotubes; sarcopenia; muscle atrophy
Funding
- Italian Space Agency (ASI) [2021-13-U.0]
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Piezo1 channels play a crucial role in the physiology of skeletal muscle, particularly in controlling myogenic precursor activity and the regeneration and vascularization of skeletal muscle. Pharmacological activation of Piezo1 channels with Yoda1 has shown potential in promoting skeletal muscle regeneration and may be a promising therapeutic strategy for skeletal muscle disorders.
Piezo1 channels are highly mechanically-activated cation channels that can sense and transduce the mechanical stimuli into physiological signals in different tissues including skeletal muscle. In this focused review, we summarize the emerging evidence of Piezo1 channel-mediated effects in the physiology of skeletal muscle, with a particular focus on the role of Piezo1 in controlling myogenic precursor activity and skeletal muscle regeneration and vascularization. The disclosed effects reported by pharmacological activation of Piezo1 channels with the selective agonist Yoda1 indicate a potential impact of Piezo1 channel activity in skeletal muscle regeneration, which is disrupted in various muscular pathological states. All findings reported so far agree with the idea that Piezo1 channels represent a novel, powerful molecular target to develop new therapeutic strategies for preventing or ameliorating skeletal muscle disorders characterized by an impairment of tissue regenerative potential.
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