Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 13, Pages -Publisher
MDPI
DOI: 10.3390/ijms23137324
Keywords
microRNA; cell type specificity; miRNA expression profiles; chromatin activity; miRNA-disease association
Funding
- National Natural Science Foundation of China [32070658]
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In this study, cell-type-specific miRNAs were identified using multiple correspondence analysis and Gini coefficients, resulting in collections of chromatin activity-specific miRNAs in 91 cell types and expression-specific miRNAs in 124 cell types. It was found that cell-type-specific miRNAs are closely associated with disease miRNAs, providing important clues for research on cancer prognosis and other aspects. Additionally, the online tool mirCellType was constructed for dissecting the cell type composition of complex samples with miRNA expression profiles.
MicroRNAs (miRNAs) regulate multiple transcripts and thus shape the expression landscape of a cell. Information about miRNA expression and distribution across cell types is crucial for the understanding of miRNAs' functions and their translational applications as biomarkers or therapeutic targets. In this study, we identify cell-type-specific miRNAs by combining multiple correspondence analysis and Gini coefficients to dissect miRNAs' expression profiles and chromatin activity score profiles, which results in collections of chromatin activity-specific miRNAs in 91 cell types and expression-specific miRNAs in 124 cell types. Moreover, we find that cell-type-specific miRNAs are closely associated with disease miRNAs, such as T-cell-specific miRNAs, which are closely associated with cancer prognosis. Finally, we constructed mirCellType, an online tool based on cell-type-specific miRNA signatures, to dissect the cell type composition of complex samples with miRNA expression profiles.
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