Immunomodulatory Properties of Polysaccharides from Lentinula edodes

Lentinula edodes (Berk.) Pegler, also known as shiitake mushroom, is a popular edible macrofungus and a source of numerous bioactive substances with multiple beneficial health effects. L. edodes-derived polysaccharides are the most valuable compounds, with anticancer, antioxidant, antimicrobial, and immunomodulatory properties. It has been demonstrated that their biological activity depends on the extraction method, which affects monosaccharide composition, molecular weight, branching degrees, and helical conformation. In this review, we discuss the immunomodulatory properties of various polysaccharides from L. edodes in animal models and in humans.

Automated summary

Shiitake mushroom, also known as Lentinula edodes, is a popular edible fungus that contains valuable polysaccharides with anticancer, antioxidant, antimicrobial, and immunomodulatory properties. The biological activity of these polysaccharides depends on the extraction method.