Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/ijms23116332
Keywords
marine endozoic fungus; Penicillium steckii; polyketide derivatives; natural products; structure elucidation; biological activity
Funding
- National Natural Science Foundation of China [U2006203, 41976090]
- Natural Science Foundation of Jiangsu province [BK20201211, KEXUE2020GZ02]
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Four unusual steckwaic acids E-H along with new analogues and known congeners were isolated from the organic extract of Penicillium steckii AS-324, an endozoic fungus obtained from a deep-sea coral. Their structures and configurations were determined using spectroscopic techniques. The compounds were tested for antimicrobial activities.
Four unusual steckwaic acids E-H (1-4), possessing a rarely described acrylic acid unit at C-4 (1-3) or a double bond between C-12 and C-13 (4) are reported for the first time, along with four new analogues (5-8) and two known congeners (9 and 10). They were purified from the organic extract of Penicillium steckii AS-324, an endozoic fungus obtained from a deep-sea coral Acanthogorgiidae sp., which was collected from the Magellan Seamount at a depth of 1458 m. Their structures were determined by the interpretation of NMR and mass spectroscopic data. The relative and absolute configurations were determined by NOESY correlations, X-ray crystallographic analysis, and ECD calculations. All compounds were tested for their antimicrobial activities against human- and aquatic-pathogenic bacteria and plant-related pathogenic fungi.
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