Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/ijms23126595
Keywords
metal complexes; coordination compounds; biological activity; biomedical applications; structural studies; metallodrugs; bioorganometallic chemistry; pharmacological activity; lung cancer; glioblastoma; neuroblastoma; adenocarcinoma; benzimidazole derivatives; thermogravimetric analysis; FTIR spectra; ADME analysis; MTT assay; medicinal inorganic chemistry
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In this study, a series of coordination compounds containing zinc and benzimidazole derivatives were synthesized and characterized using various analytical and spectroscopic techniques. The results indicated that these new compounds showed improved anticancer properties, as well as antibacterial and antifungal activities, demonstrating potential as antitumor agents.
Developing new, smart drugs with the anticancer activity is crucial, especially for cancers, which cause the highest mortality in humans. In this paper we describe a series of coordination compounds with the element of health, zinc, and bioactive ligands, benzimidazole derivatives. By way of synthesis we have obtained four compounds named C1, C2, C4 and C4. Analytical analyses (elemental analysis (EA), flame atomic absorption spectrometry (FAAS)), spectroscopic (Fourier transform infrared spectroscopy (FT-IR), mass spectrometry (MS)) and thermogravimetric (TG) methods and the definition of crystal structures were used to explore the nature of bonding and to elucidate the chemical structures. The collected analytical data allowed the determination of the stoichiometry in coordination compounds, thermal stability, crystal structure and way of bonding. The cytotoxicity effect of the new compounds as a potential antitumor agent on the glioblastoma (T98G), neuroblastoma (SK-N-AS) and lung adenocarcinoma (A549) cell lines and human normal skin fibroblasts (CCD-1059Sk) was also determined. Cell viability was determined by the MTT assay. The results obtained confirmed that conversion of ligands into the respective metal complexes significantly improved their anticancer properties. The complexes were screened for antibacterial and antifungal activities. The ADME technique was used to determine the physicochemical and biological properties.
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