4.7 Article

Altered Balance of Reelin Proteolytic Fragments in the Cerebrospinal Fluid of Alzheimer's Disease Patients

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

New Strategies for the Treatment of Neuropsychiatric Disorders Based on Reelin Dysfunction

Yumi Tsuneura et al.

Summary: Reelin, an important protein for brain development and function, is found to be associated with neuropsychiatric disorders. Supplementing Reelin could improve learning and neuronal dysfunctions in animal models. Therefore, studying the role of Reelin in neuropsychiatric disorders and potential therapeutic approaches is of great significance.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Review Biochemistry & Molecular Biology

Regulation of Reelin functions by specific proteolytic processing in the brain

Mitsuharu Hattori et al.

Summary: The glycoprotein Reelin plays crucial roles in brain development and function, including regulating neuronal migration, dendrite development, synaptogenesis, and synaptic plasticity. Loss or decreased function of Reelin may contribute to the onset and deterioration of neuropsychiatric diseases. Studies suggest that the proteolytic cleavage of Reelin may have central roles in brain development.

JOURNAL OF BIOCHEMISTRY (2021)

Review Medicine, General & Internal

Alzheimer's disease

Philip Scheltens et al.

Summary: Alzheimer's disease is projected to see a significant increase in prevalence in the future, with genetics playing a key role. Novel biomarkers and lifestyle-based prevention trials show promising therapeutic potential. Promising pharmacological treatments are advancing in clinical trials, targeting amyloid beta, tau, and inflammation.

LANCET (2021)

Article Biochemistry & Molecular Biology

Analysis of Reelin signaling and neurodevelopmental trajectory in primary cultured cortical neurons with RELN deletion identified in schizophrenia

Yumi Tsuneura et al.

Summary: Reelin, a crucial extracellular matrix protein secreted by Cajal-Retzius cells, plays important roles in brain development and neuronal functions. Reductions in Reelin are associated with brain dysfunctions in mental disorders like schizophrenia. A recent study identified a novel deletion in RELN encoding Reelin in Japanese schizophrenia patients, leading to abnormalities in brain structures and social behavior.

NEUROCHEMISTRY INTERNATIONAL (2021)

Review Clinical Neurology

Modifiable risk factors for dementia and dementia risk profiling. A user manual for Brain Health Services-part 2 of 6

Janice M. Ranson et al.

Summary: The article discusses the development of new Brain Health Services for dementia prevention, emphasizing risk analysis and personalized risk reduction interventions. It suggests selecting appropriate risk assessment tools based on age and risk level, while considering modifiable risk factors.

ALZHEIMERS RESEARCH & THERAPY (2021)

Article Genetics & Heredity

Advances in Genetics and Epigenetic Alterations in Alzheimer's Disease: A Notion for Therapeutic Treatment

Ruben Rabaneda-Bueno et al.

Summary: Alzheimer's disease is a disabling neurodegenerative disorder that greatly reduces life expectancy, yet the mechanisms underlying its onset are not fully understood. Epigenetic mechanisms have attracted attention in recent years for their role in understanding age-related changes and neurological diseases.

GENES (2021)

Review Biochemistry & Molecular Biology

APOE Genotype and Alzheimer's Disease: The Influence of Lifestyle and Environmental Factors

Efthalia Angelopoulou et al.

Summary: Alzheimer's disease is a common neurodegenerative disorder with complex pathogenesis and no disease-modifying therapy currently available. The interplay between genetic factors and environmental exposures, particularly the APOE gene alleles, may influence the risk of developing AD. Various lifestyle habits and environmental factors, such as physical exercise, dietary habits, and exposure to certain substances, have been shown to potentially interact with APOE alleles in affecting AD risk.

ACS CHEMICAL NEUROSCIENCE (2021)

Article Biochemistry & Molecular Biology

The structure-function relationship of a signaling-competent, dimeric Reelin fragment

Liam S. Turk et al.

Summary: Reelin plays a role in various aspects of brain development and function through both canonical and non-canonical pathways. The dimeric central fragment of Reelin is essential for activating the canonical pathway, forming a parallel dimer with flexibility between the protein chains. This unique conformation allows Reelin to bind to lipoprotein receptors in a way inaccessible to its monomeric form and stimulate canonical pathway signaling.

STRUCTURE (2021)

Article Geriatrics & Gerontology

Apolipoprotein E isoforms differentially regulate matrix metallopeptidase 9 function in Alzheimer's disease

Charis Ringland et al.

NEUROBIOLOGY OF AGING (2020)

Article Neurosciences

Proteases Upregulation in Sporadic Alzheimer's Disease Brain

Alessandro Medoro et al.

JOURNAL OF ALZHEIMERS DISEASE (2019)

Article Neurosciences

Multiplex proteomics identifies novel CSF and plasma biomarkers of early Alzheimer's disease

Christopher D. Whelan et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2019)

Review Clinical Neurology

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

Clifford R. Jack et al.

ALZHEIMERS & DEMENTIA (2018)

Review Neurosciences

Apolipoprotein E, Receptors, and Modulation of Alzheimer's Disease

Na Zhao et al.

BIOLOGICAL PSYCHIATRY (2018)

Article Biochemistry & Molecular Biology

Decreased generation of C-terminal fragments of ApoER2 and increased reelin expression in Alzheimer's disease

Trinidad Mata-Balaguer et al.

FASEB JOURNAL (2018)

Review Biochemistry & Molecular Biology

The ApoE receptors Vldlr and Apoer2 in central nervous system function and disease

Courtney Lane-Donovan et al.

JOURNAL OF LIPID RESEARCH (2017)

Article Neurosciences

Secreted Metalloproteinase ADAMTS-3 Inactivates Reelin

Himari Ogino et al.

JOURNAL OF NEUROSCIENCE (2017)

Article Geriatrics & Gerontology

Presenilin 1 mutations influence processing and trafficking of the ApoE receptor apoER2

Wei Wang et al.

NEUROBIOLOGY OF AGING (2017)

Review Medicine, Research & Experimental

The amyloid hypothesis of Alzheimer's disease at 25years

Dennis J. Selkoe et al.

EMBO MOLECULAR MEDICINE (2016)

Review Neurosciences

Reelin in Alzheimer's Disease, Increased Levels but Impaired Signaling: When More is Less

Inmaculada Cuchillo-Ibanez et al.

JOURNAL OF ALZHEIMERS DISEASE (2016)

Article Neurosciences

Cerebrospinal fluid Presenilin-1 increases at asymptomatic stage in genetically determined Alzheimer's disease

Aitana Sogorb-Esteve et al.

MOLECULAR NEURODEGENERATION (2016)

Article Neurosciences

ANALYSIS OF GENETICS AND RISK FACTORS OF ALZHEIMER'S DISEASE

M. Panpalli Ates et al.

NEUROSCIENCE (2016)

Article Multidisciplinary Sciences

The β-amyloid peptide compromises Reelin signaling in Alzheimer's disease

Inmaculada Cuchillo-Ibanez et al.

SCIENTIFIC REPORTS (2016)

Article Biochemistry & Molecular Biology

Reelin protects against amyloid β toxicity in vivo

Courtney Lane-Donovan et al.

SCIENCE SIGNALING (2015)

Article Biochemistry & Molecular Biology

Reelin protects against amyloid β toxicity in vivo

Courtney Lane-Donovan et al.

SCIENCE SIGNALING (2015)

Article Biochemistry & Molecular Biology

ApoER2 processing by presenilin-1 modulates reelin expression

Valeria Balmaceda et al.

FASEB JOURNAL (2014)

Article Biochemistry & Molecular Biology

Ligand-induced Homotypic and Heterotypic Clustering of Apolipoprotein E Receptor 2

Shailaja D. Divekar et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Review Neurosciences

Soluble apoE/Aβ complex: mechanism and therapeutic target for APOE4-induced AD risk

Leon M. Tai et al.

MOLECULAR NEURODEGENERATION (2014)

Review Neurosciences

ApoE and Aβ in Alzheimer's Disease: Accidental Encounters or Partners?

Takahisa Kanekiyo et al.

NEURON (2014)

Article Multidisciplinary Sciences

Reelin delays amyloid-beta fibril formation and rescues cognitive deficits in a model of Alzheimer's disease

Lluis Pujadas et al.

NATURE COMMUNICATIONS (2014)

Article Multidisciplinary Sciences

Beta-Amyloid Impairs Reelin Signaling

Inmaculada Cuchillo-Ibanez et al.

PLOS ONE (2013)

Article Neurosciences

CSF Presenilin-1 complexes are increased in Alzheimer's disease

Maria-Salud Garcia-Ayllon et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2013)

Article Neurosciences

Reelin Depletion is an Early Phenomenon of Alzheimer's Pathology

Arne Herring et al.

JOURNAL OF ALZHEIMERS DISEASE (2012)

Article Biochemistry & Molecular Biology

The Metalloprotease Meprin β Generates Amino Terminal-truncated Amyloid β Peptide Species

Jessica Bien et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Medicine, Research & Experimental

Apolipoprotein E and Apolipoprotein E Receptors: Normal Biology and Roles in Alzheimer Disease

David M. Holtzman et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)

Article Biochemistry & Molecular Biology

Metalloprotease Meprin β Generates Nontoxic N-terminal Amyloid Precursor Protein Fragments in Vivo

Tamara Jefferson et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

Functional Importance of Covalent Homodimer of Reelin Protein Linked via Its Central Region

Norihisa Yasui et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Neurosciences

β-amyloid controls altered Reelin expression and processing in Alzheimer's disease

Arancha Botella-Lopez et al.

NEUROBIOLOGY OF DISEASE (2010)

Article Multidisciplinary Sciences

ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling

Ying Chen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Multidisciplinary Sciences

Reelin signaling antagonizes β-amyloid at the synapse

Murat S. Durakoglugil et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Multidisciplinary Sciences

Reelin expression and glycosylation patterns are altered in Alzheimer's disease

A Botella-López et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Biochemistry & Molecular Biology

Receptor clustering is involved in reelin signaling

V Strasser et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)

Review Neurosciences

Reelin and brain development

F Tissir et al.

NATURE REVIEWS NEUROSCIENCE (2003)

Article Neurosciences

Altered levels of cerebrospinal fluid reelin in frontotemporal dementia and Alzheimer's disease

J Sáez-Valero et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2003)

Article Neurosciences

Secreted Reelin molecules form homodimers

K Kubo et al.

NEUROSCIENCE RESEARCH (2002)

Article Biochemical Research Methods

Multiplex detection and quantitation of proteins on Western blots using fluorescent probes

JC Gingrich et al.

BIOTECHNIQUES (2000)

Article Multidisciplinary Sciences

Expression of reelin in adult mammalian blood, liver, pituitary pars intermedia, and adrenal chromaffin cells

NR Smalheiser et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)