Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 14, Pages -Publisher
MDPI
DOI: 10.3390/ijms23147989
Keywords
progesterone; progestin; progestagen; progestogen; neurosteroid; pregnancy; gynecology; miscarriage; preterm birth; menopause; CNS disorder; endocrine disruption
Funding
- MH CZ-DRO, Institute of Endocrinology EU [00023761]
- Czech Health Research Council from the Czech Ministry of Health [NU21J-01-00040]
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Progesterone, traditionally associated with female fertility and pregnancy, has various novel actions, particularly neuro- and immunoprotective activities. It is widely used in reproductive medicine and has the potential for application in other medical fields. Its physiological and pharmacological actions, as well as its impact on the environment, have been researched and documented.
Progesterone is a steroid hormone traditionally linked with female fertility and pregnancy. In current reproductive medicine, progesterone and its analogues play crucial roles. While the discovery of its effects has a long history, over recent decades, various novel actions of this interesting steroid have been documented, of which its neuro- and immunoprotective activities are the most widely discussed. Discoveries of the novel biological activities of progesterone have also driven research and development in the field of progesterone analogues used in human medicine. Progestogen treatment has traditionally and predominately been used in maintaining pregnancy, the prevention of preterm labor, various gynecological pathologies, and in lowering the negative effects of menopause. However, there are also various other medical fields where progesterone and its analogues could find application in the future. The aim of this work is to show the mechanisms of action of progesterone and its metabolites, the physiological and pharmacological actions of progesterone and its synthetic analogues in human medicine, as well as the impacts of its production and use on the environment.
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