Better healthcare can reduce the risk of COVID-19 in-hospital post-partum maternal death: evidence from Brazil

Article Obstetrics & Gynecology

Pregnancy and risk of COVID-19: a Norwegian registry-linkage study

M. C. Magnus et al.

Summary: The study found that pregnant women were not more likely to be infected with SARS-CoV-2, but pregnant women, especially those born outside of Scandinavia, were more likely to be hospitalized with COVID-19.

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY (2022)

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Article Obstetrics & Gynecology

Is pregnancy a risk factor for in-hospital mortality in reproductive-aged women with SARS-CoV-2 infection? A nationwide retrospective observational cohort study

Char Leung et al.

Summary: Pregnancy was found to be associated with lower risk for in-hospital mortality as well as longer survival time compared with non-pregnant women after adjustment for various factors, indicating a potential protective effect on COVID-19 in pregnant women.

INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS (2022)

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Review Medicine, General & Internal

Association between IL-6 and severe disease and mortality in COVID-19 disease: a systematic review and meta-analysis

Xiaohui Liu et al.

Summary: IL-6 is a reliable predictor for severe disease in patients with COVID-19, but it does not seem to be a good indicator for mortality. This finding may assist clinicians in identifying potentially severe or critical COVID-19 patients at an early stage of the disease.

POSTGRADUATE MEDICAL JOURNAL (2022)

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Review Respiratory System

COVID-19, immunothrombosis and venous thromboembolism: biological mechanisms

Joan Loo et al.

Summary: Thrombotic events in COVID-19, especially venous thromboemboli, are associated with disease severity and poor clinical outcomes. Distinctive microvascular abnormalities include endothelial inflammation, disruption of intercellular junctions, and microthrombi formation. COVID-19 can lead to immunothrombosis, and a better understanding of the pathobiological mechanisms is crucial for developing new treatments.

THORAX (2021)

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Article Public, Environmental & Occupational Health

Emergency Care Gap in Brazil: Geographical Accessibility as a Proxy of Response Capacity to Tackle COVID-19

Lincoln Luis Silva et al.

Summary: The Brazilian Health Care System is unevenly distributed across the country, leading to inadequate preparedness to manage the COVID-19 pandemic. Public measures of the municipal and federal administrations aggravated the pandemic in Brazil.

FRONTIERS IN PUBLIC HEALTH (2021)

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Article Multidisciplinary Sciences

Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil

Nuno R. Faria et al.

Summary: A new variant of concern, P.1, with 17 mutations including three spike protein mutations associated with increased binding to human ACE2 receptors, emerged in Manaus, Brazil between November 2020 and January 2021. Molecular analysis suggests P.1 may be 1.7- to 2.4-fold more transmissible and that previous infection may provide 54 to 79% protection against P.1 infection compared to other lineages. Enhanced global genomic surveillance of such variants is crucial for pandemic response.

SCIENCE (2021)

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Article Obstetrics & Gynecology

Disease severity, pregnancy outcomes, and maternal deaths among pregnant patients with severe acute respiratory syndrome coronavirus 2 infection in Washington State

Erica M. Lokken et al.

Summary: The study showed that pregnant patients with COVID-19 had significantly higher hospitalization and case-fatality rates compared to similarly aged adults in Washington State. The hospitalization rate was 3.5 times higher than that of nonpregnant adults, and the COVID-19 case fatality rate in pregnancy was significantly elevated as well.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2021)

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Article Infectious Diseases

Characteristics and outcomes of pregnant women with SARS-CoV-2 infection and other severe acute respiratory infections (SARI) in Brazil from January to November 2020

Lisiane F. Leal et al.

Summary: In Brazil, pregnant and recently pregnant women with SARI, especially COVID-19, have higher mortality rates, particularly in regions with already high maternal mortality rates.

BRAZILIAN JOURNAL OF INFECTIOUS DISEASES (2021)

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Article Cardiac & Cardiovascular Systems

Inflammation, Infection and Venous Thromboembolism

Meaghan E. Colling et al.

Summary: The association between inflammation, infection, and venous thrombosis is crucial and can lead to pathological thrombosis. Cells like neutrophils, monocytes, and platelets play essential roles in host defense and thrombus formation. Understanding these mechanisms has advanced knowledge in human physiology and pathophysiology, offering new therapeutic targets for the treatment of thrombosis.

CIRCULATION RESEARCH (2021)

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Article Obstetrics & Gynecology

Mortality in pregnancy and the postpartum period in women with severe acute respiratory distress syndrome related to COVID-19 in Brazil, 2020

Carlos A. Scheler et al.

Summary: The study compared the fatality rates of COVID-19-related ARDS between pregnant/postpartum women and nonpregnant women, finding that pregnant/postpartum women had a lower fatality rate, with higher rates of comorbidity among fatal cases and deaths concentrated in the third trimester or postpartum period.

INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS (2021)

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Article Obstetrics & Gynecology

Maternal deaths due to COVID-19 disease: The cases in a single center pandemic hospital in the south east of Turkey

Ihsan Bagli et al.

Summary: This study examined four cases of maternal mortality in pregnant women with COVID-19 in a single pandemic center in Turkey. It emphasizes the need for cautious monitoring during the postpartum period after cesarean section and the urgent establishment of appropriate medications and treatment algorithms due to the rapid deterioration observed in the cases.

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH (2021)

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Article Pediatrics

Clinical characteristics and risk factors for death among hospitalised children and adolescents with COVID-19 in Brazil: an analysis of a nationwide database

Eduardo A. Oliveira et al.

Summary: This study found that death from COVID-19 in children and adolescents is associated with factors such as age, Indigenous ethnicity, poor geopolitical region, and pre-existing medical conditions. These disparities can contribute to magnifying the burden of COVID-19 in vulnerable and socioeconomically disadvantaged populations in Brazil.

LANCET CHILD & ADOLESCENT HEALTH (2021)

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Article Medical Informatics