Population pharmacokinetics of unbound ceftriaxone in a critically ill population

Department of Hospital Pharmacy, VieCuri Medical Center, Tegelseweg 210, 5912 BL Venlo, The Netherlands, partment 0.18 +/- 0.08 h-1. Dosing simulations predicted fT>4 mg /L of 88% (95% CI: 69 - 100%) for 2,000 mg ceftriaxone once daily and fT>4 mg /L of 100% (95% CI: 100 - 100%) both for 1,000 mg twice daily and continuous in-fusion of 2,000 mg daily. Conclusion: We de-veloped a reliable population PK model for unbound ceftriaxone in a critically ill popu-lation. Dosing simulations revealed fT>4 mg/L >= 60% for 1,000 mg twice daily and 2,000 mg once daily or by continuous infusion.

Automated summary

This study developed a reliable population PK model for unbound ceftriaxone in critically ill patients, and dosing simulations revealed that 1,000 mg twice daily, 2,000 mg once daily, or continuous infusion of 2,000 mg daily can achieve fT>4 mg/L>=60%.