Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 108, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.intimp.2022.108754
Keywords
Spinal cord injury; Astrocyte; Microglia; Neuroinflammation; Immunoregulation
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Funding
- National Natural Science Foundation of China [81960299, 82160599]
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This study reviews the effects of neuroinflammation on SCI, with a focus on the contributions and interactions of microglia and astrocytes. It also discusses therapeutic strategies to regulate their immunophenotype in order to suppress inflammation and improve injury prognosis.
Spinal cord injury (SCI) is a catastrophic event which is still without adequate therapies. Neuroinflammation is the main pathogenesis of secondary damage post-SCI, leading to tissue loss and neurological dysfunction. Previous studies have shown that microglia and astrocytes are the major immune cells in the central nervous system (CNS) and play a crucial role in modulating neuroinflammatory responses. In this study, we mainly review the effects of neuroinflammation in SCI, focusing on the contributions of microglia and astrocytes and their crosstalk. Furthermore, we will also discuss therapeutic strategies on how to regulate their immunophenotype to suppress robust inflammation and facilitate injury prognosis.
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