Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 108, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.intimp.2022.108881
Keywords
Interleukin-10 family; Osteoporosis; Bone fracture; Osteoarthritis; Bone tumors
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IL-10 family cytokines play crucial regulatory roles in bone and joint diseases and can provide novel directions for immunotherapy.
Interleukin (IL)-10 family cytokines include IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, IL-28A, IL-28B, and IL-29. These cytokines play crucial regulatory roles in various biological reactions and diseases. In recent years, several studies have shown that the IL-10 family plays a vital role in bone and joint diseases, including bone metabolic diseases, fractures, osteoarthritis, rheumatoid arthritis, and bone tumors. Herein, the recent progress on the regulatory role of IL-10 family of cytokines in the occurrence and development of bone and joint diseases has been summarized. This review will provide novel directions for immunotherapy of bone and joint diseases.
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