4.2 Article

Prolonged COVID-19 in an Immunocompromised Patient Treated with Obinutuzumab and Bendamustine for Follicular Lymphoma

Related references

Note: Only part of the references are listed.
Article Immunology

Duration of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infectivity: When Is It Safe to Discontinue Isolation?

Chanu Rhee et al.

Summary: SARS-CoV-2 is most contagious around symptom onset, with infectivity rapidly decreasing to near-zero afterwards; mild-moderately ill patients can safely discontinue isolation after about 10 days, while severely-critically ill and immunocompromised patients may need 15 days. The longest duration associated with replication-competent virus is 20 days.

CLINICAL INFECTIOUS DISEASES (2021)

Article Immunology

Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 Replication in an Immunocompromised Patient

Ji Hoon Baang et al.

Summary: This case illustrates challenges in managing immunocompromised hosts with chronic COVID-19, who may act as persistent shedders and sources of transmission. The patient's lack of seroconversion and prolonged course highlight the importance of humoral immunity in resolving viral infections.

JOURNAL OF INFECTIOUS DISEASES (2021)

Article Infectious Diseases

Prolonged viral shedding of SARS-CoV-2 in an immunocompromised patient

Yukiko Nakajima et al.

Summary: A COVID-19 case with advanced malignant lymphoma and chemotherapy experienced prolonged viral shedding for 2 months, eventually being discharged with negative PCR results on Day 69. Immunocompromised status may prolong viral shedding, highlighting the importance for clinicians to consider this factor.

JOURNAL OF INFECTION AND CHEMOTHERAPY (2021)

Article Immunology

Long-Term Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infectiousness Among Three Immunocompromised Patients: From Prolonged Viral Shedding to SARS-CoV-2 Superinfection

Hassan Tarhini et al.

Summary: This study describes the clinical evolutions and viral mutations of 3 deeply immunocompromised patients, revealing prolonged infectious viral shedding in some cases. Understanding the mechanisms and frequency of prolonged infectiousness is crucial for optimizing isolation policies.

JOURNAL OF INFECTIOUS DISEASES (2021)

Article Hematology

Prolonged in-hospital stay and higher mortality after Covid-19 among patients with non-Hodgkin lymphoma treated with B-cell depleting immunotherapy

Remy Dulery et al.

Summary: Age >= 70 years, relapsed/refractory lymphoma, and recent administration of anti-CD20 therapy are risk factors for prolonged length of in-hospital stay and death for lymphoma patients hospitalized for Covid-19.

AMERICAN JOURNAL OF HEMATOLOGY (2021)

Article Oncology

2021 update of the AGIHO guideline on evidence-based management of COVID-19 in patients with cancer regarding diagnostics, viral shedding, vaccination and therapy

Nicola Giesen et al.

Summary: The global spread of SARS-CoV-2 and COVID-19 presents unique challenges to medical staff, patients, and their families, particularly for cancer patients. This concise update provides evidence-based recommendations for rapid diagnostics, viral shedding, vaccination, and therapy of COVID-19 in cancer patients, aiming to improve clinical management for this specific population.

EUROPEAN JOURNAL OF CANCER (2021)

Article Medicine, General & Internal

Comparison of Time to Clinical Improvement With vs Without Remdesivir Treatment in Hospitalized Patients With COVID-19

Brian T. Garibaldi et al.

Summary: This comparative effectiveness research study showed that the receipt of remdesivir was associated with faster clinical improvement in a cohort of predominantly non-White patients with COVID-19. Additionally, the combination of remdesivir and corticosteroids did not reduce the time to death compared with remdesivir administered alone.

JAMA NETWORK OPEN (2021)

Article Oncology

Patterns of seroconversion for SARS-CoV-2 IgG in patients with malignant disease and association with anticancer therapy

Astha Thakkar et al.

Summary: The study found differential rates of SARS-CoV-2 IgG seroconversion in cancer patients based on specific cancer types and therapy modalities. Patients with hematological malignancies, those receiving anti-CD-20 antibody therapy, and stem cell transplant patients had significantly lower seroconversion rates, while patients receiving immunotherapy, especially anti-PD-1/PD-L1 monoclonal antibodies, showed 100% seroconversion rates. These findings have implications for clinical monitoring and vaccination strategies to combat the COVID-19 pandemic.

NATURE CANCER (2021)

Article Hematology

Risk Factors and Mortality of COVID-19 in Patients With Lymphoma: A Multicenter Study

Isabel Regalado-Artamendi et al.

Summary: This study examined the impact of COVID-19 on patients with lymphoma, finding that factors like age, confusion, urea concentration, and respiratory rate, as well as active disease, were associated with higher mortality risk. Additionally, continued presence of the virus after week six significantly increased mortality rates.

HEMASPHERE (2021)

Review Medicine, General & Internal

Remdesivir for the treatment of COVID-19

Kelly Ansems et al.

Summary: The results from five randomized controlled trials suggest that remdesivir has little or no effect on all-cause mortality at up to 28 days among hospitalized adults with SARS-CoV-2 infection. Uncertainty remains regarding the effects of remdesivir on clinical improvement and worsening. Future studies should provide more data to draw more reliable conclusions about the potential benefits and harms of remdesivir.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2021)