Journal
INORGANIC CHEMISTRY
Volume 61, Issue 24, Pages 9328-9338Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.inorgchem.2c01091
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Funding
- National Natural Science Foundation of China [52102348, 22171123, 22005259]
- Key Scientific and Technological Project of Henan province, China [212102310073]
- Key Scientific Research Project of Higher Education of Henan Province [21A150003]
- Training Plan for Young Backbone Teachers of Colleges and Universities in Henan [2019GGJS198]
- Luoyang Normal University [2018XJGGJS-11]
- City University of Hong Kong [9610495]
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This study demonstrates the growth of Cu2O nanoparticles on 2D Zr-ferrocene-MOF nanosheets to prepare 2D composites for photothermally enhanced chemodynamic antibacterial therapy. The Cu2O/Zr-Fc-MOF composite shows higher chemodynamic activity than the pristine Zr-Fc-MOF nanosheets, and this activity can be further enhanced by NIR laser irradiation.
Two-dimensional (2D) metal- organic framework (MOF) nanosheets have been demonstrated to be promising templates for the growth of various kinds of nanomaterials on their surfaces to construct novel 2D composites, thus realizing enhanced performance in various applications. Herein, we report the growth of Cu2O nanoparticles on 2D Zr-ferrocene (Zr-Fc)-MOF (Zr-Fc-MOF) nanosheets to prepare 2D composites for near-infrared (NIR) photothermally enhanced chemodynamic antibacterial therapy. The uniform Zr-Fc-MOF nanosheets are synthesized using the solvothermal method, followed by ultrasound sonication, and Cu2O nanoparticles are then deposited on its surface to obtain the Cu2O-decorated Zr-Fc-MOF (denoted as Cu2O/Zr-Fc-MOF) 2D composite. Promisingly, the Cu2O/Zr-Fc-MOF composite shows higher chemodynamic activity for producing center dot OH via Fenton-like reaction than that of the pristine Zr-Fc-MOF nanosheets. More importantly, the chemodynamic activity of the Cu2O/Zr-Fc-MOF composite can be further enhanced by the photothermal effect though NIR laser (808 nm) irradiation. Thus, the Cu2O/Zr-Fc-MOF composite can be used as an efficient nanoagent for photothermally enhanced chemodynamic antibacterial therapy.
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