4.5 Article

Crohn's Disease Patients Uniquely Contain Inflammatory Responses to Flagellin in a CD4 Effector Memory Subset

Related references

Note: Only part of the references are listed.
Article Immunology

Flagellin-Specific CD4 Cytokine Production in Crohn Disease and Controls Is Limited to a Small Subset of Antigen-Induced CD40L+ T Cells

Nadine N. Morgan et al.

Summary: Flagellin is a dominant antigen in Crohn's disease, and only a small fraction of CD154-enriched cells in patients showed antigen-reactive cytokine responses. Antigen-reactive CD4 cytokine production was restricted to CD4 cells with an effector memory phenotype and the highest levels of induced CD154 expression, which has implications for identifying specific T cells for single cell cloning, phenotyping, and transcriptomics.

JOURNAL OF IMMUNOLOGY (2021)

Article Gastroenterology & Hepatology

Human Microbiota Flagellins Drive Adaptive Immune Responses in Crohn's Disease

Katie L. Alexander et al.

Summary: This study demonstrates that patients with Crohn's disease have strong adaptive immune responses to human-derived Lachnospiraceae flagellins, with elevated serum IgG levels and specific T cell responses associated with disease complications. These findings suggest that targeting these specific flagellins may hold promise for prognosis and personalized therapies in the future.

GASTROENTEROLOGY (2021)

Article Gastroenterology & Hepatology

Anti-Microbial Antibody Response is Associated With Future Onset of Crohn's Disease Independent of Biomarkers of Altered Gut Barrier Function, Subclinical Inflammation, and Genetic Risk

Sun-Ho Lee et al.

Summary: High baseline total positive antibody response is associated with an increased risk of developing CD in the future, independently of abnormal gut barrier function, subclinical inflammation, and CD-related genetic risks. Causal mediation analysis showed that the effect of high AS on future CD development is partially mediated through preclinical gut inflammation.

GASTROENTEROLOGY (2021)

Article Gastroenterology & Hepatology

Analysis of Flagellin Specific Adaptive Immnunity Reveals Links to Dysbioss in Patients With Inflammatory Bowel Disease

Laura Cook et al.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2020)

Article Gastroenterology & Hepatology

Commensal-Specific CD4+ Cells From Patients With Crohn's Disease Have a T-Helper 17 Inflammatory Profile

Elisabeth Calderon-Gomez et al.

GASTROENTEROLOGY (2016)

Article Pharmacology & Pharmacy

Role of defective methylation reactions in ethanol-induced dysregulation of intestinal barrier integrity

Paul G. Thomes et al.

BIOCHEMICAL PHARMACOLOGY (2015)

Article Allergy

Human seroreactivity to gut microbiota antigens

Benjamin S. Christmann et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2015)

Review Immunology

Microbiota activation and regulation of innate and adaptive immunity

Katie L. Alexander et al.

IMMUNOLOGICAL REVIEWS (2014)

Article Gastroenterology & Hepatology

Serological markers predict inflammatory bowel disease years before the diagnosis

Fiona D. M. van Schaik et al.

Article Gastroenterology & Hepatology

Serum Antibodies Associated with Complex Inflammatory Bowel Disease

Abdul A. Elkadri et al.

INFLAMMATORY BOWEL DISEASES (2013)

Article Multidisciplinary Sciences

CD4+CD62L+ Central Memory T Cells Can Be Converted to Foxp3+ T Cells

Xiaolong Zhang et al.

PLOS ONE (2013)

Article Gastroenterology & Hepatology

Regulation of Homeostasis and Inflammation in the Intestine

Thomas T. MacDonald et al.

GASTROENTEROLOGY (2011)

Review Multidisciplinary Sciences

Intestinal homeostasis and its breakdown in inflammatory bowel disease

Kevin J. Maloy et al.

NATURE (2011)

Review Gastroenterology & Hepatology

Microbial influences in inflammatory bowel diseases

R. Balfour Sartor

GASTROENTEROLOGY (2008)

Article Gastroenterology & Hepatology

Enhanced CBirl-specific Innate and Adaptive Immune Responses in Crohn's Disease

Chong Shen et al.

INFLAMMATORY BOWEL DISEASES (2008)

Article Gastroenterology & Hepatology

Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice

Charles O. Elson et al.

GASTROENTEROLOGY (2007)

Article Medicine, Research & Experimental

IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6

D Yen et al.

JOURNAL OF CLINICAL INVESTIGATION (2006)

Article Gastroenterology & Hepatology

Elevated flagellin-specific immunoglobulins in Crohn's disease

SV Sitaraman et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2005)

Article Gastroenterology & Hepatology

TNF-α-induced increase in intestinal epithelial tight junction permeability requires NF-κB activation

TY Ma et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2004)

Article Medicine, Research & Experimental

Bacterial flagellin is a dominant antigen in Crohn disease

MJ Lodes et al.

JOURNAL OF CLINICAL INVESTIGATION (2004)

Article Multidisciplinary Sciences

Induction of colitis by a CD4+ T cell clone specific for a bacterial epitope

MC Kullberg et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)