☆ 4.5 Editorial Material

Type 2 alveolar epithelial cell-derived circulating extracellular vesicle-encapsulated surfactant protein C as a mediator of cardiac inflammation in COVID-19

INFLAMMATION RESEARCH (2022)

Related references

Note: Only part of the references are listed.

Review Emergency Medicine

COVID-19 associated myocarditis: A systematic review

William Haussner et al.

Summary: COVID-19 can lead to primary acute heart failure from viral myocarditis or Takotsubo cardiomyopathy, with similar incidence. The main difference between COVID-19-associated myocarditis and respiratory failure is the presence of an early shock state.

AMERICAN JOURNAL OF EMERGENCY MEDICINE (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Cardioprotection of M2 macrophages-derived exosomal microRNA-24-3p/Tnfsf10 axis against myocardial injury after sepsis

XingCheng Sun et al.

Summary: This study demonstrates that miR-24-3p derived from M2 macrophage exosomes can protect against myocardial injury after sepsis by reducing the expression of Tnfsfl0.

MOLECULAR IMMUNOLOGY (2022)

Add to Collection

Article Geriatrics & Gerontology

Plasma exosomes characterization reveals a perioperative protein signature in older patients undergoing different types of on-pump cardiac surgery

Alessandro Carrozzo et al.

Summary: The study found that the endogenous cardioprotection in older cardiac surgery patients is mediated early by distinct exosomal proteins regardless of the type of surgery.

GEROSCIENCE (2021)

Add to Collection

Article Cardiac & Cardiovascular Systems

Myocarditis is rare in COVID-19 autopsies: cardiovascular findings across 277 postmortem examinations

Marc K. Halushka et al.

Summary: The COVID-19 pandemic is associated with significant cardiovascular involvement, with common cardiovascular histopathological findings reported in autopsied hearts. However, the true prevalence of conditions such as myocarditis may be lower than initially thought. Further research is needed to clarify the exact impact of COVID-19 on cardiovascular health.

CARDIOVASCULAR PATHOLOGY (2021)

Add to Collection

Article Medicine, Research & Experimental

Dysregulation of miR-342-3p in plasma exosomes derived from convalescent AMI patients and its consequences on cardiac repair

Bo Wang et al.

Summary: Plasma exosomes derived from convalescent AMI patients showed impaired ability to repair damaged cardiomyocytes compared to those from healthy controls, potentially due to dysregulation of miR-342-3p. The study also revealed that miR-342-3p promoted exosome-mediated heart repair by targeting SOX6 and TFEB to inhibit cardiomyocyte apoptosis and autophagy. These findings provide insights into the role of plasma exosomes in cardiac repair after AMI and suggest potential therapeutic strategies.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Add to Collection

Article Multidisciplinary Sciences

A molecular single-cell lung atlas of lethal COVID-19

Johannes C. Melms et al.

Summary: Single-nucleus RNA sequencing of lung tissues from individuals who died of COVID-19 revealed a highly inflamed lung environment with impaired T cell responses and failed transition of alveolar type 2 cells. Additionally, expansion of pathological fibroblasts contributing to rapidly ensuing pulmonary fibrosis in COVID-19 was identified as a unique feature compared to other causes of pneumonia.

NATURE (2021)

Add to Collection

Article Biology

SnRNA sequencing defines signaling by RBC-derived extracellular vesicles in the murine heart

Nedyalka Valkov et al.

Life Science Alliance (2021)

Add to Collection

Article Medicine, General & Internal

Presence of SARS-CoV-2 Nucleoprotein in Cardiac Tissues of Donors with Negative COVID-19 Molecular Tests

Gianluca Lorenzo Perrucci et al.

Summary: This study investigated the presence of SARS-CoV-2 in cardiac tissues obtained from donors in Lombardy, Italy, and found that while viral RNA was not detected in the donors, variable levels of viral nucleoprotein signal were present in some tissues, suggesting caution and further investigations on implantable tissue specimens collected during the COVID-19 pandemic.

DIAGNOSTICS (2021)

Add to Collection

Article Cardiac & Cardiovascular Systems

Echocardiographic Characteristics and Outcome in Patients With COVID-19 Infection and Underlying Cardiovascular Disease

Yuman Li et al.

Summary: Patients with COVID-19 infection and underlying CVD showed impaired LV diastolic and RV function, with RV dysfunction being the most common, particularly associated with elevated hs-TNI levels and the need for mechanical ventilation therapy, while LV systolic or diastolic function was relatively normal. The parameters of RV function were predictive of higher mortality in these patients.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

Add to Collection

Article Hematology

Extracellular vesicles from thalassemia patients carry iron-containing ferritin and hemichrome that promote cardiac cell proliferation

Anyapat Atipimonpat et al.

Summary: Extracellular vesicles from beta-thal patients may contain iron-load proteins that lead to the induction of cardiac cell proliferation. While both normal and thal patients' microparticles promoted cardiac cell proliferation, only exosomes from thal patients had this effect. Additionally, exosomes from thal patients with iron overload potentially induce higher cardiac cell proliferation and angiogenesis compared to those without iron overload and normal controls.

ANNALS OF HEMATOLOGY (2021)

Add to Collection

Article Cell Biology

Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes

Clair Crewe et al.

Summary: Adipocytes under energetic stress release sEVs containing damaged mitochondrial particles, which enter circulation and trigger antioxidant signaling in cardiomyocytes, protecting them from oxidative stress. This functional mitochondrial transfer between tissues provides potent cardio-protection against stresses induced by obesity.

CELL METABOLISM (2021)

Add to Collection

Article Cell Biology

Extracellular vesicle-mediated endothelial apoptosis and EV-associated proteins correlate with COVID-19 disease severity

Balaji Krishnamachary et al.

Summary: The protein cargo in EVs can distinguish the severity of COVID-19, with enrichment of proinflammatory, procoagulation, immunoregulatory, and tissue-remodeling proteins. These proteins induce apoptosis of pulmonary microvascular endothelial cells.

JOURNAL OF EXTRACELLULAR VESICLES (2021)

Add to Collection

Article Toxicology

Development of alveolar and airway cells from human iPS cells: toward SARS-CoV-2 research and drug toxicity testing

Kayoko Tsuji et al.

Summary: This study generated ATII and club cells from human induced pluripotent stem cells (hiPSCs) for SARS-CoV-2 infection and drug testing, providing a useful in vitro model for drug development. The differentiated cells expressing ACE2 and TMPRSS2 were infected with SARS-CoV-2, and treatments with Remdesivir and bleomycin showed promising results in inhibiting viral replication and inducing cytotoxicity. These findings suggest the hiPSC-derived AT2 and club cells are valuable tools for studying COVID-19 pathogenesis and drug development.

JOURNAL OF TOXICOLOGICAL SCIENCES (2021)

Add to Collection

Article Biochemistry & Molecular Biology

HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19

Mingfu Tian et al.

Summary: The cytokine storm induced by SARS-CoV-2 is a major pathological feature of COVID-19, with HIF-1α and pro-inflammatory cytokines playing key roles in infection and inflammatory responses. The production of HIF-1α, inflammatory responses, and high mortalities in elderly patients indicate its crucial role in exacerbating COVID-19.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Add to Collection

Article Endocrinology & Metabolism

A multi-omics investigation of the composition and function of extracellular vesicles along the temporal trajectory of COVID-19

Sin Man Lam et al.

Summary: This study analyzed exosome-enriched extracellular vesicles from patients at different stages of COVID-19, highlighting dysregulated lipid metabolism in the hyperinflammatory phase and distinct metabolic and transcriptional responses triggered by EVs from different temporal phases in recipient cells. The results provide insights into cellular lipid metabolism and inter-tissue crosstalk at different stages of COVID-19 and contribute to understanding metabolic dysregulation in COVID-19.

NATURE METABOLISM (2021)

Add to Collection

Article Physiology

Hypoxia induces expression of angiotensin-converting enzyme II in alveolar epithelial cells: Implications for the pathogenesis of acute lung injury in COVID-19

Anne Sturrock et al.

Summary: SARS-CoV-2 enters lung epithelial cells by binding to ACE2, which can lead to the development of acute respiratory distress syndrome in COVID-19 patients.

PHYSIOLOGICAL REPORTS (2021)

Add to Collection

Review Physiology

SARS CoV-2 related microvascular damage and symptoms during and after COVID-19: Consequences of capillary transit-time changes, tissue hypoxia and inflammation

Leif Ostergaard

Summary: COVID-19 infection can cause symptoms in multiple organs, including low blood oxygen levels, muscle pain, fatigue, and mood changes. Capillary damage and inflammation may play a role in these symptoms.

PHYSIOLOGICAL REPORTS (2021)

Add to Collection

Article Cardiac & Cardiovascular Systems

Small Extracellular Microvesicles Mediated Pathological Communications Between Dysfunctional Adipocytes and Cardiomyocytes as a Novel Mechanism Exacerbating Ischemia/Reperfusion Injury in Diabetic Mice

Lu Gan et al.

CIRCULATION (2020)

Add to Collection

Article Medicine, General & Internal

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China

Dawei Wang et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Add to Collection

Letter Immunology

On the molecular determinants of the SARS-CoV-2 attack

Darja Kanduc et al.

CLINICAL IMMUNOLOGY (2020)

Add to Collection

Article Cardiac & Cardiovascular Systems

Extracellular vesicular MicroRNA-27a*contributes to cardiac hypertrophy in chronic heart failure

Changhai Tian et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2020)

Add to Collection

Article Cell & Tissue Engineering

Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction

Hiroaki Katsura et al.

CELL STEM CELL (2020)

Add to Collection

Article Cell & Tissue Engineering

SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response

Jessie Huang et al.

CELL STEM CELL (2020)

Add to Collection

Article Cell & Tissue Engineering

Detection of viral RNA fragments in human iPSC cardiomyocytes following treatment with extracellular vesicles from SARS-CoV-2 coding sequence overexpressing lung epithelial cells

Youjeong Kwon et al.

STEM CELL RESEARCH & THERAPY (2020)

Add to Collection

Article Medicine, Research & Experimental

Inflammatory extracellular vesicles prompt heart dysfunction via TRL4-dependent NF-kappa B activation

Vanessa Biemmi et al.

THERANOSTICS (2020)

Add to Collection

Article Cardiac & Cardiovascular Systems

Longterm Exercise-Derived Exosomal miR-342-5p A Novel Exerkine for Cardioprotection

Zuoxu Hou et al.

CIRCULATION RESEARCH (2019)

Add to Collection

Article Oncology

Exosome Analysis in Tumor-Draining Pulmonary Vein Identifies NSCLC Patients with Higher Risk of Relapse after Curative Surgery

Alfons Navarro et al.

CANCERS (2019)

Add to Collection

Article Medicine, Research & Experimental

Exosomal microRNA-122 mediates obesity-related cardiomyopathy through suppressing mitochondria ADP-ribosylation factor-like 2

Yongshun Wang et al.

CLINICAL SCIENCE (2019)

Add to Collection

Review Physiology

Extracellular vesicles in lung health, disease, and therapy

Mark J. McVey et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2019)

Add to Collection

Article Toxicology

Mesenchymal stem cell-derived exosomes attenuate phosgene-induced acute lung injury in rats

Ning Xu et al.

INHALATION TOXICOLOGY (2019)

Add to Collection

Article Endocrinology & Metabolism

Exosomal microRNA-29a mediates cardiac dysfunction and mitochondrial inactivity in obesity-related cardiomyopathy

Fengqin Li et al.

ENDOCRINE (2019)

Add to Collection

Article Physiology

Serum-Derived Extracellular Vesicles Protect Against Acute Myocardial Infarction by Regulating miR-21/PDCD4 Signaling Pathway

Huanyu Gu et al.

FRONTIERS IN PHYSIOLOGY (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Exosomal microRNA-194 causes cardiac injury and mitochondrial dysfunction in obese mice

Hezhongrong Nie et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Add to Collection

Article Physiology

Intonation of Nrf2 and Hif1-alpha pathway by curcumin prophylaxis: A potential strategy to augment survival signaling under hypoxia

Titto Mathew et al.

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY (2018)

Add to Collection

Article Clinical Neurology

MiR-126 Affects Brain-Heart Interaction after Cerebral Ischemic Stroke

Jieli Chen et al.

TRANSLATIONAL STROKE RESEARCH (2017)

Add to Collection

Review Anatomy & Morphology

Lung surfactant: Function and composition in the context of development and respiratory physiology

Wolfgang Bernhard

ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER (2016)

Add to Collection

Article Cardiac & Cardiovascular Systems

Plasma Exosomes Protect the Myocardium From Ischemia-Reperfusion Injury

Jose M. Vicencio et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2015)

Add to Collection

Article Cell Biology

Lung epithelial cell-derived extracellular vesicles activate macrophage-mediated inflammatory responses via ROCK1 pathway

H-G Moon et al.

CELL DEATH & DISEASE (2015)

Add to Collection

Article Medicine, Research & Experimental

MicroRNA-146a is a therapeutic target and biomarker for peripartum cardiomyopathy

Julie Halkein et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Add to Collection

Article Multidisciplinary Sciences

Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis

Jiang Chang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Add to Collection

© Peeref 2019-2024. All rights reserved.