Journal
IMMUNOLOGIC RESEARCH
Volume 70, Issue 5, Pages 644-653Publisher
SPRINGER
DOI: 10.1007/s12026-022-09296-7
Keywords
Lupus nephritis; Systemic lupus erythematosus; Th17 cells; Th1 cells; Cytokines
Categories
Funding
- International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy [S/MAR18-01]
Ask authors/readers for more resources
The differentiation of Th1/Th17 cells is altered in systemic lupus erythematosus (SLE), which has a significant impact on the development and severity of the disease.
Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by T cells imbalance. Indeed, a correlation between levels of Th17 cells and disease activity has been reported. Our work aimed to study the functional association of subpopulations of Th cells and SLE with (lupus nephritis, LN) or without (lupus erythematosus, LE) renal involvement in Tunisian patients through the detection of intracellular cytokines and surface marker expression. The IL23R and RORC mRNA expression levels were evaluated. The level of Th17 and Th1 cells was higher in LE and LN patients compared to healthy controls (HC) (p = 0.007 and p = 0.018, respectively), while Th1/17 cells were increased only in LN patients compared to HC (p = 0.011). However, no significant difference was described in the mRNA expression levels of RORC and IL-23R between SLE and HC. Our findings suggest that the Th1/Th17 differentiation mechanisms are altered in SLE and that this imbalance should have an important influence on the development and severity of the disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available