Journal
IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS
Volume 19, Issue 4, Pages 2158-2165Publisher
IEEE COMPUTER SOC
DOI: 10.1109/TCBB.2021.3056570
Keywords
DNA; Support vector machines; Deep learning; Data models; Biological system modeling; Training; Supervised learning; DNA barcoding; deep learning; convolutional neural network; species classification; sequence analysis
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Funding
- Ministry of Science and Technology, R.O.C. [107-2811E-992-500-, 107-2221-E-214-013, 107-2811-E-992-500-]
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DNA barcodes are short sequence fragments used for species identification. This study proposes a deep learning framework, called deep barcoding, for species classification using DNA barcodes. By utilizing raw sequence data and deep convolutional neural networks, the deep barcoding model achieves high accuracy in species identification. Although there are challenges, the deep barcoding model has the potential to be an effective tool for species classification.
DNA barcodes with short sequence fragments are used for species identification. Because of advances in sequencing technologies, DNA barcodes have gradually been emphasized. DNA sequences from different organisms are easily and rapidly acquired. Therefore, DNA sequence analysis tools play an increasingly crucial role in species identification. This study proposed deep barcoding, a deep learning framework for species classification by using DNA barcodes. Deep barcoding uses raw sequence data as the input to represent one-hot encoding as a one-dimensional image and uses a deep convolutional neural network with a fully connected deep neural network for sequence analysis. It can achieve an average accuracy of >90 percent for both simulation and real datasets. Although deep learning yields outstanding performance for species classification with DNA sequences, its application remains a challenge. The deep barcoding model can be a potential tool for species classification and can elucidate DNA barcode-based species identification.
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