Journal
IEEE SENSORS JOURNAL
Volume 22, Issue 15, Pages 14686-14695Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/JSEN.2022.3185457
Keywords
Nanobioscience; Current measurement; Optical sensors; Optical variables measurement; Biomedical optical imaging; Electric potential; Optical filters; Nanopore; translocation measurement; optical detection; electrical detection; low noise
Funding
- Scientific and Useful Profound Research Advancement (SUPRA) Program of the Science Engineering Research Board (SERB) [SPR/2021/000275]
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In recent years, nanopore has emerged as a promising single molecule sensor for label-free detection of biomolecules. By incorporating optical techniques, the intrinsic property and heterogeneity of a single molecule can be better understood. This review summarizes the recent advancements in electrical and optical sensing in nanopores.
In recent years, nanopore has promisingly emerged as a single molecule sensor and is able to detect biomolecules in a label-free manner. Much progress has been made in biotechnological applications using electrical measurement of temporal changes in ionic current. But it has its own limitation with respect to noise, throughput, spatial and temporal resolutions. By incorporating the optical techniques, we can acquire information about the intrinsic property and heterogeneity of a single molecule. Here we review the recent advancements in electrical and optical sensing in nanopores.
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