Clear cell stromal tumour of the lung with YAP1::TFE3 fusion: four cases including a case with highly aggressive clinical course

Article Oncology

A YAP1::TFE3 cutaneous low-grade fibromyxoid neoplasm: A novel entity!

Ashley Patton et al.

Summary: Cutaneous fibromyxoid neoplasms (CFMN) encompass a wide range of benign and malignant tumors with varying treatment implications. This report describes a rare CFMN case featuring a YAP1::TFE3 fusion, morphologically distinct from previously described cases, suggesting a potential new entity within the CFMN spectrum.

GENES CHROMOSOMES & CANCER (2022)

Add to Collection

Article Pathology

Recurrent YAP1-TFE3 Gene Fusions in Clear Cell Stromal Tumor of the Lung

Abbas Agaimy et al.

Summary: Clear cell (hemangioblastoma-like) stromal tumor of the lung (CCST-L) is a recently described rare pulmonary neoplasm, potentially driven by YAP1-TFE3 fusion. These tumors exhibit unique histological features and further large series studies are needed to elucidate their biological behavior.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2021)

Add to Collection

Article Cell Biology

YAP1-TFE3 gene fusion variant in clear cell stromal tumour of lung: report of two cases in support of a distinct entity

Josephine K. Dermawan et al.

Summary: This study described two cases of clear cell stromal tumour of the lung with YAP1-TFE3 gene fusion. The fusion breakpoints were identified in YAP1 exon 4 and TFE3 exon 7, distinguishing them from other similar tumors. Both tumors showed diffusely positive for nuclear TFE3 and have not recurred or metastasized after complete surgical resection.

HISTOPATHOLOGY (2021)

Add to Collection

Article Pathology

YAP1-TFE3-fused hemangioendothelioma: a multi-institutional clinicopathologic study of 24 genetically-confirmed cases

Josephine K. Dermawan et al.

Summary: YAP1-TFE3-fused hemangioendothelioma is a rare malignant vascular tumor with a female predominance. It commonly occurs in soft tissue and bone. Different histopathological patterns and variable expression of certain proteins, but consistent presence of YAP1-TFE3 gene fusion, were observed. Surgical resection is a common treatment approach and patients generally have a favorable prognosis.

MODERN PATHOLOGY (2021)

Add to Collection

Article Pathology