Journal
HEMATOLOGICAL ONCOLOGY
Volume 40, Issue 5, Pages 835-842Publisher
WILEY
DOI: 10.1002/hon.3037
Keywords
chronic lymphocytic leukemia; flow cytometry; measurable residual disease
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Measurable residual disease (MRD) is a relevant parameter for assessing the response to therapy in chronic lymphocytic leukemia (CLL). Flow cytometry has emerged as the most useful and standardized approach for measuring and quantifying MRD. The increased sensitivity of MRD measurements has led to improved therapeutic strategies for CLL, making MRD detection more applicable in this context.
Measurable residual disease (MRD) has emerged as a relevant parameter of response to therapy in chronic lymphocytic leukemia (CLL). Although several methods have been developed, flow cytometry has emerged as the most useful and standardized approach to measure and quantify MRD. The improved sensitivity of MRD measurements has been paralleled by the development of more effective therapeutic strategies for CLL, increasing the applicability of MRD detection in this setting. Chemotherapy and chemoimmunotherapy have firstly demonstrated their ability to obtain a deep MRD. Combined targeted therapies are also demonstrating a high molecular response rate and prospective trials are exploring the role of MRD to guide the duration of treatment in this setting. In this review we briefly summarize what we have learned about MRD with emphasis on its flow cytometric detection.
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