HNF4A Defines Molecular Subtypes and Vulnerability to Transforming Growth Factor β-Pathway Targeted Therapies in Cancers of the Distal Esophagus

Review Oncology

Overcoming TGFβ-mediated immune evasion in cancer

Daniele V. F. Tauriello et al.

Summary: This review discusses the role of TGF beta in the tumour immune microenvironment and the importance of TGF beta inhibition in restoring cancer immunity. TGF beta controls multiple cell fate decisions during development and tissue homeostasis, and dysregulation of this pathway can lead to various diseases including cancer. The context-dependent functions of TGF beta in the tumour microenvironment play a crucial role in suppressing or promoting cancer.

NATURE REVIEWS CANCER (2022)

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Article Oncology

Epidemiology and Outcomes of Young-Onset Esophageal Adenocarcinoma: An Analysis from a Population-Based Database

Don C. Codipilly et al.

Summary: The incidence of young-onset esophageal adenocarcinoma is increasing, with a higher proportion presenting at advanced stages and experiencing poorer outcomes compared to older patients. Current diagnostic and management strategies for this population may need to be reevaluated.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2021)

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Review Oncology

The role of transforming growth factor β in upper gastrointestinal cancers: A systematic review

Linde M. Veen et al.

Summary: Esophageal and gastric malignancies have poor prognosis due to recurrences or metastases after treatment, with the TGF-beta pathway potentially playing a role in treatment resistance. Preclinical studies showed that TGF-beta enhances hallmarks of cancer in most gastric and esophageal cancer cell lines, but not in all. Targeting the TGF-beta pathway could be a promising strategy in these cancer patients, but further clinical trials are necessary to define the specific patient groups that would benefit the most.

CANCER TREATMENT REVIEWS (2021)

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Article Oncology