4.8 Editorial Material

The Microbiome Modifies the Effect of Diet on Colorectal Cancer Incidence

Related references

Note: Only part of the references are listed.
Article Gastroenterology & Hepatology

Western-Style Diet, pks Island-Carrying Escherichia coil, and Colorectal Cancer: Analyses From Two Large Prospective Cohort Studies

Kota Arima et al.

Summary: This study found that a Western-style diet is associated with a higher incidence of colorectal cancer containing abundant pks(+) E coli, providing further support for a potential link between diet, the intestinal microbiota, and colorectal carcinogenesis.

GASTROENTEROLOGY (2022)

Article Multidisciplinary Sciences

Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response

Christine N. Spencer et al.

Summary: The study suggests that dietary fiber intake is associated with significantly improved progression-free survival in melanoma patients receiving ICB treatment, especially without the use of probiotics. Preclinical studies demonstrate that a low-fiber diet or probiotics can impair the treatment response to anti-PD-1 therapy, leading to a lower frequency of interferon-gamma-positive cytotoxic T cells in the tumor microenvironment.

SCIENCE (2021)

Article Multidisciplinary Sciences

Mutational signature in colorectal cancer caused by genotoxic pks+E. coli

Cayetano Pleguezuelos-Manzano et al.

NATURE (2020)

Article Multidisciplinary Sciences

Escherichia coli induces DNA double-strand breaks in eukaryotic cells

Jean-Philippe Nougayrede et al.

SCIENCE (2006)