Journal
FUTURE MICROBIOLOGY
Volume 17, Issue 12, Pages 943-956Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/fmb-2021-0240
Keywords
antibiotic-associated diarrhea; compound probiotics; fecal microbiota; fecal morphology; gut microbiota
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Funding
- Natural Science Foundation of Guangdong Province [2020A1515011268]
- Key-Area Research and Development Program of Guangdong province [2020B020226008, 2018B020206001]
- China Agriculture Research System of MOF [CARS-21]
- China Agriculture Research System of MARA [CARS-21]
- Guangdong Provincial Special Fund for Modern Agriculture Industry Technology Innovation Teams [2019KJ125]
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Combining probiotic beverages effectively treats antibiotic-associated diarrhea, and the S1 formula shows the best efficacy in restoring the structure of the gut and fecal microbiota.
Probiotics and their products are the classic way to treat and prevent gastrointestinal diseases. In this study, the authors designed new combinations and doses of probiotic beverages for antibiotic-associated diarrhea. Group S1 was different from the other groups, including Lactobacillus rhamnosus HN001, Lactobacillus acidophilus NCFM and Bifidobacterium lactis BI-07. Its inulin content was higher than those of the other groups. Mice were induced with a 16-day administration of triple antibiotics in advance for 2 weeks prior to antibiotic treatment. In the experiment, the treatment group returned to normal more quickly than the placebo group. In group S1, the relative abundance of the phylum Firmicutes and genus Lactobacillus increased, and the structure of the microbiota was the closest to normal among all groups. In conclusion, the combinations of probiotic beverages effectively caused structural recovery of the gut and fecal microbiota against antibiotic-associated diarrhea, and the S1 formula showed the best efficacy.
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