Journal
FRONTIERS IN HUMAN NEUROSCIENCE
Volume 16, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnhum.2022.924155
Keywords
brain-derived neurotrophic factor; TrkB; stroke; depression; anxiety; neurodegenerative disease
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Funding
- National Natural Science Foundation of China [81873108, 81603321]
- University Nursing Program for Young Scholars with Creative Talents in Heilongjiang Province [UNPYSCT-2017216]
- Excellent Creative Talents Support Program of Heilongjiang University of Chinese Medicine [2018RCQ08]
- Research Foundation of Heilongjiang University of Chinese Medicine [2019BJP02]
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This article reviews the abnormal levels of brain-derived neurotrophic factor (BDNF) in various central nervous system (CNS) diseases and suggests that BDNF may play a role in the pathogenesis of these diseases. It also discusses the potential treatment of these diseases by regulating BDNF signaling. The clinical application status of BDNF is briefly introduced.
Recent studies have found abnormal levels of brain-derived neurotrophic factor (BDNF) in a variety of central nervous system (CNS) diseases (e.g., stroke, depression, anxiety, Alzheimer's disease, and Parkinson's disease). This suggests that BDNF may be involved in the pathogenesis of these diseases. Moreover, regulating BDNF signaling may represent a potential treatment for such diseases. With reference to recent research papers in related fields, this article reviews the production and regulation of BDNF in CNS and the role of BDNF signaling disorders in these diseases. A brief introduction of the clinical application status of BDNF is also provided.
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