4.7 Article

Polysaccharides from Cordyceps militaris prevent obesity in association with modulating gut microbiota and metabolites in high-fat diet-fed mice

Journal

FOOD RESEARCH INTERNATIONAL
Volume 157, Issue -, Pages -

Publisher

ELSEVIER
DOI: 10.1016/j.foodres.2022.111197

Keywords

Cordyceps militaris; Polysaccharide; Obesity; Inflammation; Gut microbiota; Metabolites

Funding

  1. Guangdong Major Project of Basic and Applied Basic Research [2020B0301030005]
  2. 2020 Guangdong Recruitment Program of Foreign Experts [2020A1414010038]
  3. Special Project of Science and Technology Development [2019GDASYL-0201001, 2020GDASYL-202003010]
  4. Guangdong Provincial Key Laboratory [2020B121201009]

Ask authors/readers for more resources

This study found that polysaccharides from Cordyceps militaris (CMP) can improve obesity symptoms in high-fat diet-fed mice by modulating gut microbes and related metabolites.
Improved gut microbes and nutritious metabolites have been considered as the mediators of health benefits from indigestible polysaccharides, but their role in the anti-obesity effect of polysaccharides from Cordyceps militaris (CMP) remains elusive. This study aims to explore the potential mediators of the anti-obesity effects of CMP in high-fat diet (HFD)-fed mice using 16S rRNA sequencing and untargeted metabolomics analysis. The results showed that CMP supplementation in HFD-fed mice reduced body weight, fat accumulation, pro-inflammatory cytokine levels, and impaired glucose tolerance as well as gut barrier. Moreover, the CMP reversed the HFD-induced gut microbiota dysbiosis, as indicated by the elevated population of Alloprevotella, Parabacteroides, Butyricimonas, and Alistipes; and decreased population of Negativebacillus, in addition to altered levels of me-tabolites, such as brassicasterol and 4 & PRIME;-O-methylkanzonol W. Notably, CMP prevented obesity in association with the altered gut microbes and metabolites. These findings suggest that CMP may serve as a potential prebiotic agent to modulate specific gut microbes and related metabolites, which play a critical role in its preventing obesity-related diseases.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available